Expression of Beta-Catenin in Hilar Cholangiocarcinoma and Relevance to the Expression of c-myc Gene_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHENG Qichang ¹ , CHEN Haibo ² , ZUO Keqiang ¹ , ZHANG Yong. ¹

Department of Hepatic and Biliary Surgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,China;

Corresponding author：

Keywords：

β-catenin Hilar cholangiocarcinoma c-myc gene

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【Abstract】ObjectiveTo investigate whether abnormal expression of β-catenin and high expression of c-myc have played a possible role in hilar cholangiocarcinoma carcinogenesis.
MethodsBy using immunohitochemical staining (SP method), the authors detected the expression of β-catenin and c-myc in 42 paraffin-embedded samples of hilar cholangiocarcinoma and 10 benign bile duct disease tissue, and then analyzed the relationship of them with clinical data.
Resultsβ-catenin was normally expressed in 10 benign bile duct disease tissue, while expression of c-myc was negtive. In hilar cholangiocarcinoma tissue, the positive expression rate of β-catenin （71.4%） was significantly correlated to the lymphoid node metastasis of hilar cholangiocarcinoma (χ2=4.75，P＜0.05),but was not statistically correlated to the tumor size，the extent of differentiation and infiltration (χ2=3.35，3.45，4.32，P gt;0.05); the expression rate of c-myc (76.2%) was correlated with the extent of differentiation(χ2=4.87, P＜0.05),but not with the size, infiltration, lymphoid metastasis（χ2= 3.47，4.12，2.76， P gt;0.05). The abnormal expression of β-catenin had relevance to the high expression of c-myc with hilar cholangiocarcinoma （r=0.324,P＜0.01）.
ConclusionThe expression of beta-catenin and c-myc is significantly altered in hilar cholangiocarcinoma, and correlate with biological features of cholangiocarcinoma.The abnormal expression of beta-catenin is one of the mechanisms for the spread of hilar cholangiocarcinoma.

Citation： ZHENG Qichang,CHEN Haibo,ZUO Keqiang,ZHANG Yong.. Expression of Beta-Catenin in Hilar Cholangiocarcinoma and Relevance to the Expression of c-myc Gene. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(1): 67-70. doi: Copy

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2. He TC, Sparks AB, Rago C, et al. Identification of cmyc as a target of the APC pathway [Ｊ]. Science，1998； 281（5）∶ 1509.
3. Jawhari A, Jordan S, Poole S, et al. Abnormal immunoreactivity of the Ecadherincatenin complex in gastric cancer: relationship with patient survival [Ｊ]. Gastroenterology, 1997； 112（4）∶46.
4. Fromowitz FB, Steinbook ML, Lautin EM, et al. ras p21 expression in the progression of breast cancer [Ｊ]. Hum Pathol， 1987； 18(12)∶1268.
5. Tetsu O, McCormick F. betacatebub regulates expression of cyclinD1 in colon carcinoma cells [Ｊ]. Nature， 1999； 398(6726)∶422.
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8. 臧桐，庄立岩，张志文，等. β连环蛋白基因在肾癌中的表达及其突变分析 [Ｊ].中华泌尿外科杂志,2000； 21(6)∶328.
9. Ougolkov A, Yamashita K, Bilim V, et al. Abnormal expression of Ecadherin, betacatenin, and cerbB2 in advanced gastric cancer: its association with liver metastasis [Ｊ]. Int J Colorectal Dis， 2003； 18(2)∶160.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Beta-Catenin in Hilar Cholangiocarcinoma and Relevance to the Expression of c-myc Gene

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