Changes of Pancreatic Microcirculation in Early Phase of Acute Pancrentitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JIA Penghui , ZHANG Zhaoda.

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Acute pancreatitis Microcirculation Therapy

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【Abstract】Objective To study the change of pancreatic microcirculation in the early phase of acute pancreatitis.
MethodsLiteratures on acute pancreatitis and microcirculation were collected and reviewed.
ResultsPancreatic microcirculation has changed in the early phase of acute pancreatitis, including contraction of interlobular arteriole, slowing of blood fluid, increasing of pancreatic vascular permeability, leukocyte adherence in postcapillary venules, and decreasing of pancreatic perfusion.
Conclusion Impairment of pancreatic microcirculation in the early phase of acute pancreatitis may play a key role in the progression of this disease.

Citation： JIA Penghui,ZHANG Zhaoda.. Changes of Pancreatic Microcirculation in Early Phase of Acute Pancrentitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(1): 92-94. doi: Copy

1.	Kaska M, Pospisilova B, Slizova D. Pathomorphological changes in microcirculation of pancreas during experimental acute pancreatitis [J]. Hepatogastroenterology, 2000; 47(36)∶1570.
2.	Zhou ZG, Chen YD, Sun W, et al.Pancreatic microcirculatory impairment in experimental acute pancreatitis in rats [J]. World J Gastroenterol, 2002; 8(5)∶933.
3.	von Dobschuetz E, Biberthaler P, Mussack T, et al. Noninvasive in vivo assessment of the pancreatic microcirculation: orthogonal polarization spectral imaging [J]. Pancreas, 2003; 26(2)∶139.
4.	Schmidt J, Ebeling D, Ryschich E, et al. Pancreatic capillary blood flow in an improved model of necrotizing pancreatitis in the rat [J]. J Surg Res， 2002; 106(2)∶335.
5.	Benz S, Obermaier R, Wiessner R, et al. Effect of nitric oxide in ischemia/reperfusion of the pancreas [J]. J Surg Res， 2002; 106(1)∶46.
6.	Foitzik T, Eibl G, Hotz B, et al. Persistent multiple organ microcirculatory disorders in severe acute pancreatitis: experimental findings and clinical implications [J]. Dig Dis Sci，2002; 47(1)∶130.
7.	Halonen KI, Pettila V, Leppaniemi AK, et al. Multiple organ dysfunction associated with severe acute pancreatitis [J]. Crit Care Med， 2002; 30(6)∶1274.
8.	Obermaier R, Benz S, von Dobschuetz E, et al. Characterization of microcirculatory disturbance in a novel model of pancreatic ischemiareperfusion using intravital fluorescencemicroscopy [J]. Pancreas, 2002; 25(2)∶142.
9.	Bhatia M, Brady M, Shokuhi S, et al. Inflammatory mediators in acute pancreatitis [J]. J Pathol, 2000; 190(2)∶117.
10.	Benz S, Bergt S, Obermaier R, et al. Impairment of microcirculation in the early reperfusion period predicts the degree of graft pancreatitis in clinical pancreas transplantation [J]. Transplantation, 2001; 71(6)∶759.
11.	Plusczyk T, Bersal B, Westermann S, et al. ET1 induces pancreatitislike microvascular deterioration and acinar cell injury [J]. J Surg Res, 1999; 85(2)∶301.
12.	Foitzik T, Eibl G, Hotz HG, et al. Endothelin receptor blockade in severe acute pancreatitis leads to systemic enhancement of microcirculation, stabilization of capillary permeability, and improved survival rates [J]. Surgery, 2000; 128(3)∶399.
13.	Coskun T, Korkusuz P, Kaya Y, et al. Free oxygen radicalinduced acute pancreatitis. A light and electron microscopic study [J]. Hepatogastroenterology, 2003; 50(49)∶43.
14.	Chen HM, Sunamura M, Shibuya K, et al. Early microcirculatory derangement in mild and severe pancreatitis models in mice [J]. Surg Today, 2001; 31(7)∶634.
15.	Yucel K, Alhan E, Kucuktulu U, et al. The effects of prostaglandin E1 on the microperfusion of the pancreas during acute necrotizing pancreatitis in rats [J]. Hepatogastroenterology, 2002; 49 (44)∶544.
16.	Menger MD, Plusczyk T, Vollmar B. Microcirculatory derangements in acute pancreatitis [J]. J Hepatobiliary Pancreat Surg, 2001; 8(3)∶187.
17.	Kusterer K, Poschmann T, Friedemann A, et al. Arterial constriction, ischemiareperfusion, and lenkocyte adherence in acute pancreatitis [J]. Am J Physiol, 1993; 265(1 Pt 1)∶G167.
18.	Folch E, Closa D, Prats N, et al.Leukotriene generation and neutrophil infiltration after experimental acute pancreatitis [J]. Inflammation, 1998; 22(1)∶83.
19.	Zhou Z, Chen Y, Yu Y, et al. Hemorheology and expression of neutrophil adhesion molecules CD18 and CD62L in pancreatic microcirculation of Caerulein induced experimental acute pancreatitis [J]. Zhonghua Yu Fang Yi Xue Za Zhi, 2002; 36(7)∶528.
20.	Eibl G, Buhr HJ, Foitzik T. Therapy of microcirculatory disorders in severe acute pancreatitis: what mediators should we block? [J]. Intensive Care Med, 2002; 28(2)∶139.
21.	Shields CJ, Winter DC, Sookhai S, et al. Hypertonic saline attenuates endorgan damage in an experimental model of acute pancreatitis [J]. Br J Surg, 2000; 87(10)∶1336.
22.	张连峰, 李丽，李继昌. 改善微循环在重症胰腺炎治疗中的作用 [J]. 中国实用内科杂志， 2002; 22(3)∶163.

1. Kaska M, Pospisilova B, Slizova D. Pathomorphological changes in microcirculation of pancreas during experimental acute pancreatitis [J]. Hepatogastroenterology, 2000; 47(36)∶1570.
2. Zhou ZG, Chen YD, Sun W, et al.Pancreatic microcirculatory impairment in experimental acute pancreatitis in rats [J]. World J Gastroenterol, 2002; 8(5)∶933.
3. von Dobschuetz E, Biberthaler P, Mussack T, et al. Noninvasive in vivo assessment of the pancreatic microcirculation: orthogonal polarization spectral imaging [J]. Pancreas, 2003; 26(2)∶139.
4. Schmidt J, Ebeling D, Ryschich E, et al. Pancreatic capillary blood flow in an improved model of necrotizing pancreatitis in the rat [J]. J Surg Res， 2002; 106(2)∶335.
5. Benz S, Obermaier R, Wiessner R, et al. Effect of nitric oxide in ischemia/reperfusion of the pancreas [J]. J Surg Res， 2002; 106(1)∶46.
6. Foitzik T, Eibl G, Hotz B, et al. Persistent multiple organ microcirculatory disorders in severe acute pancreatitis: experimental findings and clinical implications [J]. Dig Dis Sci，2002; 47(1)∶130.
7. Halonen KI, Pettila V, Leppaniemi AK, et al. Multiple organ dysfunction associated with severe acute pancreatitis [J]. Crit Care Med， 2002; 30(6)∶1274.
8. Obermaier R, Benz S, von Dobschuetz E, et al. Characterization of microcirculatory disturbance in a novel model of pancreatic ischemiareperfusion using intravital fluorescencemicroscopy [J]. Pancreas, 2002; 25(2)∶142.
9. Bhatia M, Brady M, Shokuhi S, et al. Inflammatory mediators in acute pancreatitis [J]. J Pathol, 2000; 190(2)∶117.
10. Benz S, Bergt S, Obermaier R, et al. Impairment of microcirculation in the early reperfusion period predicts the degree of graft pancreatitis in clinical pancreas transplantation [J]. Transplantation, 2001; 71(6)∶759.
11. Plusczyk T, Bersal B, Westermann S, et al. ET1 induces pancreatitislike microvascular deterioration and acinar cell injury [J]. J Surg Res, 1999; 85(2)∶301.
12. Foitzik T, Eibl G, Hotz HG, et al. Endothelin receptor blockade in severe acute pancreatitis leads to systemic enhancement of microcirculation, stabilization of capillary permeability, and improved survival rates [J]. Surgery, 2000; 128(3)∶399.
13. Coskun T, Korkusuz P, Kaya Y, et al. Free oxygen radicalinduced acute pancreatitis. A light and electron microscopic study [J]. Hepatogastroenterology, 2003; 50(49)∶43.
14. Chen HM, Sunamura M, Shibuya K, et al. Early microcirculatory derangement in mild and severe pancreatitis models in mice [J]. Surg Today, 2001; 31(7)∶634.
15. Yucel K, Alhan E, Kucuktulu U, et al. The effects of prostaglandin E1 on the microperfusion of the pancreas during acute necrotizing pancreatitis in rats [J]. Hepatogastroenterology, 2002; 49 (44)∶544.
16. Menger MD, Plusczyk T, Vollmar B. Microcirculatory derangements in acute pancreatitis [J]. J Hepatobiliary Pancreat Surg, 2001; 8(3)∶187.
17. Kusterer K, Poschmann T, Friedemann A, et al. Arterial constriction, ischemiareperfusion, and lenkocyte adherence in acute pancreatitis [J]. Am J Physiol, 1993; 265(1 Pt 1)∶G167.
18. Folch E, Closa D, Prats N, et al.Leukotriene generation and neutrophil infiltration after experimental acute pancreatitis [J]. Inflammation, 1998; 22(1)∶83.
19. Zhou Z, Chen Y, Yu Y, et al. Hemorheology and expression of neutrophil adhesion molecules CD18 and CD62L in pancreatic microcirculation of Caerulein induced experimental acute pancreatitis [J]. Zhonghua Yu Fang Yi Xue Za Zhi, 2002; 36(7)∶528.
20. Eibl G, Buhr HJ, Foitzik T. Therapy of microcirculatory disorders in severe acute pancreatitis: what mediators should we block? [J]. Intensive Care Med, 2002; 28(2)∶139.
21. Shields CJ, Winter DC, Sookhai S, et al. Hypertonic saline attenuates endorgan damage in an experimental model of acute pancreatitis [J]. Br J Surg, 2000; 87(10)∶1336.
22. 张连峰, 李丽，李继昌. 改善微循环在重症胰腺炎治疗中的作用 [J]. 中国实用内科杂志， 2002; 22(3)∶163.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Changes of Pancreatic Microcirculation in Early Phase of Acute Pancrentitis

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