Expression of Presenilin-2 and Glutathione S Transferase π and Their Clinical Significance in Infiltrating Ductal Breast Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

FAN Wei , YANG Jinqiao , WU Xiaoting

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Infiltrating ductal breast carcinoma, Immunohistochemistry, Presenilin-2, Glutathione S transferase

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Objective To investigate the expression of presenilin-2(PS2) and glutathione S transferase π(GSTπ) and their role in the prognosis and therapy of infiltrating ductal breast carcinoma.
Methods The expression of PS2 and GSTπ in tumor tissues from 210 patients with infiltrating ductal breast carcinoma confirmed by pathologic examination and treated with modified radical mastectomy was examined by using LSAB immunohistochemical method.
Results The expression rate of PS2 was 49.5%(104/210) and the expression rate of GSTπ was 48.1%(101/210). The grade of the postoperative 5-year survival rate and 10-year survival rate in four groups of 210 patients, from high to low, was the group 1 (PS2 positive expression/GSTπ negative expression), the group 2 (PS2 positive expression/GSTπ positive expression), the group 3 (PS2 negative expression/GSTπ negative expression) and the group 4 (PS2 negative expression/GSTπ positive expression).
Conclusion The prognosis of the group 1 is the best, the group 2 better, the group 3 good and the group 4 the worst. The results suggest that reasonable use of endocrinotherapy and chemotherapy in infiltrating ductal breast carcinoma is necessary.

Citation： FAN Wei,YANG Jinqiao,WU Xiaoting. Expression of Presenilin-2 and Glutathione S Transferase π and Their Clinical Significance in Infiltrating Ductal Breast Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(1): 14-16. doi: Copy

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1. Ledingham IM, Mackey C. International union against cancer TNM classification of malignant tumors [A]. In: Ledingham IM, Mackey C. ed. Surgical Pathology [M]. 4th ed. Edinburgh London Melbourne and New York: Churchill Liringstone. 1998∶85.
2. McCarthy AL, Henry JA, Angns B, et al. Prognostic significance of the estrogenregulated protein, eathepsin D in breast cancer [J]. Cancer, 1990; 65(2)∶265.
3. Gairns J, Wright H, Cattan AR, et al. Immunohistochemical demonstration of glutathinone Stransterase in primary human breast carcinomas [J]. J Pathol, 1992; 166(1)∶19.
4. Tomasetto C.PS2 and breast cancer: a review of the literature [J]. BP: IGBMC, 1997; 163(9)∶19.
5. Gion M, Mione R, Pappagallo GL, et al. PS2 in breast canceralternative or complementary tool to steroid receptor status? Evaluation of 446 cases [J]. Br J Cancer， 1993; 68(2)∶374.
6. 韩小红，孙素莲. PS2一种新乳腺癌预后预示因子 [J]. 临床与实验病理学杂志， 1998； 1（8）∶74.
7. 陈高明，李春海. 乳腺癌中GSTπ和MDR1基因表达及其临床价值 [J].中国癌症研究进展， 1998； 5（6）∶81.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Presenilin-2 and Glutathione S Transferase π and Their Clinical Significance in Infiltrating Ductal Breast Carcinoma

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