Study of Relationship Between Cholecystectomy and Helicobacter Pylori Infection_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

HUANG Cheng ¹ , WU Zhimian ¹ , ZHENG Zhaoxu ¹ , LI Yong ¹ , TAN Min ¹ , FAN Jia. ²

Department of Minimally Invasive Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China;

Corresponding author：

Keywords：

Helicobacter pylori; Gallstone; Cholecystitis; Cholecystectomy

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ObjectiveTo study the relationship between cholecystectomy and Helicobacter pylori （Hp） infection. MethodsOne hundred and eleven patients with cholecystolithiasis were chosen as the investigation group, while 577 patients with upper digestive tract symptoms without cholecystolithiasis as the control group. All the patients took the 13C breath test to determine whether they were infected by Hp. All the patients with Hp infection continued eradical therapy for Hp infection for one course after cholecystectomy and were followed up on outpatient basis. ResultsThe infection rate in the investigation group was 45.9%, while 27.4% in the control group. During the 3 to 6 months of followup for the patients undergoing eradical therapy for Hp infection, we found no patient complaining of epigastric pain, malaise, belching and nausea. ConclusionThe infection rate of Hp in patients with cholecystolithiasis is high, Hp may be one of the factors causing “postcholecystectomy syndrome”. Eradical therapy for Hp after cholecystectomy will help improve the effects of operation.

Citation： HUANG Cheng,WU Zhimian,ZHENG Zhaoxu,LI Yong,TAN Min,FAN Jia.. Study of Relationship Between Cholecystectomy and Helicobacter Pylori Infection. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(4): 338-340. doi: Copy

1.	Bates T, Ebbs SR, Harrison M, et al. Influence of cholecystectomy on symptoms [Ｊ]. Br J Surg, 1991; 78(8)∶ 964.
2.	Luman W, Williams AJ, Pryde A, et al. Influence of cholecystectomy on sphincter of Oddi motility [Ｊ]. Gut, 1997; 41(3)∶371.
3.	Wilson P, Jamieson JR, Hinder RA, et al. Pathologic duodenogastric reflux associated with persistence of symptoms after cholecystectomy [Ｊ]. Surgery, 1995; 117(4)∶421.
4.	Farsakh NA, Roweily E, Steitieh M, et al. Prevalence of Helicobacter pylori in patients with gall stones before and after cholecystectomy: a longitudinal study [Ｊ]. Gut, 1995; 36(5)∶675.
5.	Caldwell MT, McDermott M, Jazrawi S, et al. Helicobacter pylori infection increases following cholecystectomy [Ｊ]. Ir J Med Sci, 1995; 164(1)∶52.
6.	Artiko VM, Chebib HY, Ugljesic MB, et al. Relationship between enterogastric reflux estimated by scintigraphy and the presence of Helicobacter pylori [Ｊ]. Hepatogastroenterology, 1999; 46(26)∶1234.
7.	Chebib H, Artiko V, Ugljesic M, et al. The presence and significance of Helicobacter pylori in patients with enterogastric reflux [Ｊ]. Acta Chir Iugosl, 1999; 46(1-2)∶53.
8.	Gnatiuk NG, Furmanenko ED, Grigorova IV, et al. Reflux gastritis due to Helicobacter pylori as the cause of unsatisfactory results of cholecystectomy [Ｊ]. Klin Khir, 1997; (1)∶16.
9.	Ladas SD, Katsogridakis J, Malamou H, et al. Helicobacter pylori may induce bile reflux: link between H pylori and bile induced injury to gastric epithelium [Ｊ]. Gut, 1996; 38(1)∶15.
10.	Manifold DK, Anggiansah A, Rowe I, et al. Gastrooesophageal reflux and duodenogastric reflux before and after eradication in Helicobacter pylori gastritis [Ｊ]. Eur J Gastroenterol Hepatol, 2001; 13(5)∶535.
11.	Zullo A, Rinaldi V, Hassan C, et al. Gastric pathology in cholecystectomy patients: role of Helicobacter pylori and bile reflux [Ｊ]. J Clin Gastroenterol, 1998; 27(4)∶335.

1. Bates T, Ebbs SR, Harrison M, et al. Influence of cholecystectomy on symptoms [Ｊ]. Br J Surg, 1991; 78(8)∶ 964.
2. Luman W, Williams AJ, Pryde A, et al. Influence of cholecystectomy on sphincter of Oddi motility [Ｊ]. Gut, 1997; 41(3)∶371.
3. Wilson P, Jamieson JR, Hinder RA, et al. Pathologic duodenogastric reflux associated with persistence of symptoms after cholecystectomy [Ｊ]. Surgery, 1995; 117(4)∶421.
4. Farsakh NA, Roweily E, Steitieh M, et al. Prevalence of Helicobacter pylori in patients with gall stones before and after cholecystectomy: a longitudinal study [Ｊ]. Gut, 1995; 36(5)∶675.
5. Caldwell MT, McDermott M, Jazrawi S, et al. Helicobacter pylori infection increases following cholecystectomy [Ｊ]. Ir J Med Sci, 1995; 164(1)∶52.
6. Artiko VM, Chebib HY, Ugljesic MB, et al. Relationship between enterogastric reflux estimated by scintigraphy and the presence of Helicobacter pylori [Ｊ]. Hepatogastroenterology, 1999; 46(26)∶1234.
7. Chebib H, Artiko V, Ugljesic M, et al. The presence and significance of Helicobacter pylori in patients with enterogastric reflux [Ｊ]. Acta Chir Iugosl, 1999; 46(1-2)∶53.
8. Gnatiuk NG, Furmanenko ED, Grigorova IV, et al. Reflux gastritis due to Helicobacter pylori as the cause of unsatisfactory results of cholecystectomy [Ｊ]. Klin Khir, 1997; (1)∶16.
9. Ladas SD, Katsogridakis J, Malamou H, et al. Helicobacter pylori may induce bile reflux: link between H pylori and bile induced injury to gastric epithelium [Ｊ]. Gut, 1996; 38(1)∶15.
10. Manifold DK, Anggiansah A, Rowe I, et al. Gastrooesophageal reflux and duodenogastric reflux before and after eradication in Helicobacter pylori gastritis [Ｊ]. Eur J Gastroenterol Hepatol, 2001; 13(5)∶535.
11. Zullo A, Rinaldi V, Hassan C, et al. Gastric pathology in cholecystectomy patients: role of Helicobacter pylori and bile reflux [Ｊ]. J Clin Gastroenterol, 1998; 27(4)∶335.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Study of Relationship Between Cholecystectomy and Helicobacter Pylori Infection

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