Prevention and Treatment for Recurrence of Hepatitis B after Liver Transplantation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Chunman , LI Li.

The Second Hospital of Kunming Medical College,Kunming 650101,China;

Corresponding author：

Keywords：

Liver transplantation Hepatitis B Immunoglobulin Interferon Famcyclovir Lamivudine

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

【Abstract】Objective To investigate the prevention and treatment for recurrence of hepatitis B after liver transplantation on HBV-related diseases.
Methods Making a literature summarization based on published papers review.
Results Acute and chronic HBV-related diseases are the main indications of liver transplantation.Recurrence rate of hepatitis B is from 80% to 100% in the untreated patients after liver transplantation,and it affects the survivals of patients seriously.It has become a focus to prevent and treat the recurrence of hepatitis B.After a series of explotation and application,there have been a lot of drugs of preventing and treating HBV reinfection, including hepatitis B immunoglobulin,interferon and nucleotide analog antivirus drugs(lamivudine, famcyclovir, adefovir),etc.The therapeutic characteristics of them are different. Their utilizations of dividing or alliance are developing rapidly.
Conclusion Liver transplatation is an effective therapy for HBV-related disease. Anti-HBV treatments perioperation play an important role in the improvement of succeed of liver transplantation.

Citation： LI Chunman,LI Li.. Prevention and Treatment for Recurrence of Hepatitis B after Liver Transplantation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(5): 416-417. doi: Copy

1.	朱晓峰，陈规划.乙肝患者肝移植后乙肝复发的防治 [J]. 肝胆外科杂志, 2000； 8（3）∶191.
2.	Angus PW. Review: hepatitis B and liver transplantation [J]. J Gastroenterol Hepatol, 1997; 12(3)∶217.
3.	袁育红，胡品津.乙型肝炎病毒感染与肝移植 [J]. 国外医学内科学分册, 1999； 26（6）∶235.
4.	Samuel D, Feray C, Bismuth H. Hepatitis viruses and liver transplantation [J]. J Gastroenterol Hepatol, 1997; 12(9-10)∶S335.
5.	贾继东，王宝恩.肝移植术后乙肝复发的预防和治疗 [J]. 中华肝脏病杂志, 2002； 10（1）∶61.
6.	Samuel D, Muller R, Alexander G, et al. Liver transplantation in European patients with the hepatitis B surface antigen [J]. N Engl J Med, 1993; 329(25)∶1842.
7.	刘勇，严律南.乙型肝炎相关肝脏疾病肝移植术后乙肝复发的预防 [J]. 外科理论与实践, 2002； 7（2）∶171.
8.	Samuel D, Bismuth A, Mathieu D, et al. Passive immunoprophylaxis after liver transplantation in HBsAgpositive patients [J]. Lancet, 1991; 337(8745)∶813.
9.	肖春云.干扰素治疗慢性病毒性肝炎的研究现状 [J]. 医学综述, 1998； 4（11）∶590.
10.	陈规划，何晓顺. 70例原位肝移植 [J]. 中华外科杂志, 2001；39（3）：679.
11.	王建设. 拉咪呋啶对慢性乙型肝炎治疗的突破及面临问题 [J]. 临床肝病杂志, 2000； 16（3）∶134.
12.	李必海. 拉咪呋啶对慢性乙型肝炎的治疗作用 [J]. 国外医学药学分册, 2000； 27（2）∶102.
13.	朱建平，张月琳.肝移植术后乙型肝炎病毒再感染的防治 [J]. 中华器官移植杂志, 2003； 24（2）∶28.
14.	郑树森，吴健.肝移植患者乙型肝炎病毒再感染的防治 [J]. 中华器官移植杂志, 2000； 21（6）∶366.
15.	Malkan G, Cattral MS, Humar A, et al. Lamivudine for hepatitis B in liver transplantation: a singlecenter experience [J]. Transplantation, 2000; 69(7)∶1403.
16.	陆坚. 核苷类似物治疗慢性乙型肝炎临床研究进展 [J]. 医学综述, 1998； 4（6）∶320.
17.	Manns MP. Famcidovir treatment of hepatitis B infection follwing liver transplantation: a longterm, multicentre study [J]. Transplant Inject Dis, 2001; 3(1)∶16.
18.	Han SH, Kinkhabwala M, Martin P, et al. Resolution of recurrent hepatitis B in two liver transplant recipients treated with famciclovir [J]. Am J Gastroenterol, 1998; 93(11)∶2245.
19.	Rayes N, Seehofer D, Hopf U, et al. Comparison of famciclovir and lamivudine in the long term treatment of hepatitis B infection after liver transplantation [J]. Transplantation, 2001; 71(1)∶96.
20.	Balzarini J, Hao Z, Herdewijn P, et al. Intracellular metabolism and mechanism of antiretrovirus action of 9(2phosphonylmethoxyethyl)adenine, a potent antihuman immunodeficiency virus compound [J]. Proc Natl Acad Sci USA, 1991; 88(4)∶1499.
21.	黄砚青，龚作炯.阿地福韦体外抗乙肝病毒的活性 [J]. 中国医院药学杂志, 2001； 21（11）∶656.
22.	Heijtink RA, De Wilde GA, Kruining J, et al. Inhibitory effect of 9(2phosphonylmethoxyethyl)adenine (PMEA) on human and duck hepatitis B virus infection [J]. Antiviral Res, 1993; 21(2)∶141.
23.	成军.阿地福韦在慢性乙型肝炎治疗中的应用 [J]. 国外医学病毒学分册, 2001； 8（3）∶85.
24.	成军. 拉米夫定在肝移植患者乙型肝炎病毒再感染防治与治疗中的应用第36届欧洲肝病年会巡礼 [J]. 国外医学病毒学分册, 2001； 8（6）∶185.
25.	Perrillo R, Schiff E, Yoshida E, et al. Adefovir dipivoxil for the treatment of lamivudineresistant hepatitis B mutants [J]. Hepatology, 2000; 32(1)∶129.
26.	严律南.肝脏良性疾病的肝移植 [J]. 中国普外基础与临床杂志， 2003； 10（4）∶321.
27.	江正辉，王槐志. 拉米夫定在肝移植中的应用情况 [J]. 胃肠病学和肝脏病学杂志, 2002； 11（3）∶ 278.

1. 朱晓峰，陈规划.乙肝患者肝移植后乙肝复发的防治 [J]. 肝胆外科杂志, 2000； 8（3）∶191.
2. Angus PW. Review: hepatitis B and liver transplantation [J]. J Gastroenterol Hepatol, 1997; 12(3)∶217.
3. 袁育红，胡品津.乙型肝炎病毒感染与肝移植 [J]. 国外医学内科学分册, 1999； 26（6）∶235.
4. Samuel D, Feray C, Bismuth H. Hepatitis viruses and liver transplantation [J]. J Gastroenterol Hepatol, 1997; 12(9-10)∶S335.
5. 贾继东，王宝恩.肝移植术后乙肝复发的预防和治疗 [J]. 中华肝脏病杂志, 2002； 10（1）∶61.
6. Samuel D, Muller R, Alexander G, et al. Liver transplantation in European patients with the hepatitis B surface antigen [J]. N Engl J Med, 1993; 329(25)∶1842.
7. 刘勇，严律南.乙型肝炎相关肝脏疾病肝移植术后乙肝复发的预防 [J]. 外科理论与实践, 2002； 7（2）∶171.
8. Samuel D, Bismuth A, Mathieu D, et al. Passive immunoprophylaxis after liver transplantation in HBsAgpositive patients [J]. Lancet, 1991; 337(8745)∶813.
9. 肖春云.干扰素治疗慢性病毒性肝炎的研究现状 [J]. 医学综述, 1998； 4（11）∶590.
10. 陈规划，何晓顺. 70例原位肝移植 [J]. 中华外科杂志, 2001；39（3）：679.
11. 王建设. 拉咪呋啶对慢性乙型肝炎治疗的突破及面临问题 [J]. 临床肝病杂志, 2000； 16（3）∶134.
12. 李必海. 拉咪呋啶对慢性乙型肝炎的治疗作用 [J]. 国外医学药学分册, 2000； 27（2）∶102.
13. 朱建平，张月琳.肝移植术后乙型肝炎病毒再感染的防治 [J]. 中华器官移植杂志, 2003； 24（2）∶28.
14. 郑树森，吴健.肝移植患者乙型肝炎病毒再感染的防治 [J]. 中华器官移植杂志, 2000； 21（6）∶366.
15. Malkan G, Cattral MS, Humar A, et al. Lamivudine for hepatitis B in liver transplantation: a singlecenter experience [J]. Transplantation, 2000; 69(7)∶1403.
16. 陆坚. 核苷类似物治疗慢性乙型肝炎临床研究进展 [J]. 医学综述, 1998； 4（6）∶320.
17. Manns MP. Famcidovir treatment of hepatitis B infection follwing liver transplantation: a longterm, multicentre study [J]. Transplant Inject Dis, 2001; 3(1)∶16.
18. Han SH, Kinkhabwala M, Martin P, et al. Resolution of recurrent hepatitis B in two liver transplant recipients treated with famciclovir [J]. Am J Gastroenterol, 1998; 93(11)∶2245.
19. Rayes N, Seehofer D, Hopf U, et al. Comparison of famciclovir and lamivudine in the long term treatment of hepatitis B infection after liver transplantation [J]. Transplantation, 2001; 71(1)∶96.
20. Balzarini J, Hao Z, Herdewijn P, et al. Intracellular metabolism and mechanism of antiretrovirus action of 9(2phosphonylmethoxyethyl)adenine, a potent antihuman immunodeficiency virus compound [J]. Proc Natl Acad Sci USA, 1991; 88(4)∶1499.
21. 黄砚青，龚作炯.阿地福韦体外抗乙肝病毒的活性 [J]. 中国医院药学杂志, 2001； 21（11）∶656.
22. Heijtink RA, De Wilde GA, Kruining J, et al. Inhibitory effect of 9(2phosphonylmethoxyethyl)adenine (PMEA) on human and duck hepatitis B virus infection [J]. Antiviral Res, 1993; 21(2)∶141.
23. 成军.阿地福韦在慢性乙型肝炎治疗中的应用 [J]. 国外医学病毒学分册, 2001； 8（3）∶85.
24. 成军. 拉米夫定在肝移植患者乙型肝炎病毒再感染防治与治疗中的应用第36届欧洲肝病年会巡礼 [J]. 国外医学病毒学分册, 2001； 8（6）∶185.
25. Perrillo R, Schiff E, Yoshida E, et al. Adefovir dipivoxil for the treatment of lamivudineresistant hepatitis B mutants [J]. Hepatology, 2000; 32(1)∶129.
26. 严律南.肝脏良性疾病的肝移植 [J]. 中国普外基础与临床杂志， 2003； 10（4）∶321.
27. 江正辉，王槐志. 拉米夫定在肝移植中的应用情况 [J]. 胃肠病学和肝脏病学杂志, 2002； 11（3）∶ 278.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Prevention and Treatment for Recurrence of Hepatitis B after Liver Transplantation

Abstract Full text Figures/Tables Video References Cited by

Format

Content