【Abstract】Objective To explore the clinical significance of β-catenin expression in pancreatic carcinoma.
Methods The immunohistochemical staining was performed to detect the expression of β-catenin in the specimens of 46 patients with pancreatic carcinoma and the results were statistically analyzed.
Results The abnormal expression rate on the membrane was 54.3%, the poorer the differentiation, the higher the abnormal expression rate. The levels of the cases in whom metastasis occurred were much higher than those without metastasis. The abnormal cytoplasm expression rate was 21.7%,which had not significant correlation with the clinical indexes, such as staging, tumor size, grading and metastasis. In 23 patients who accepted intervention chemotherapy before operation, the cytoplasm expression rate in those with tumor mass smaller was 0, which was evidently lower than that of those without tumor mass change (33.3%). Moreover, the abnormal membrane and cytoplasm expression rates had remarkable concordance (63.0%).
Conclusion The abnormal membrane expression of β-catenin may accelerate metastasis, and the abnormal expression of β-catenin in cytoplasm may result in cell proliferation.
Citation：
SUN Jian,NI Quanxing,FU Deliang,YU Xianjun,YAO Qiyuan,ZHANG Yanling.. Significance of β-Catenin Expression in Pancreatic Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(5): 440-441. doi:
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- 1. Klppel G, Maillet B. Classification and staging of pancreatic nonendocrine tumors [Ｊ]. Radiol Clin North Am， 1989; 27(1)∶ 105.
- 2. 王彩霞， 袁孟彪， 陈静. 原癌基因产物βcatenin在胃癌组织中的表达 [Ｊ]. 山东医科大学学报， 2001； 39（2）∶116.
- 3. Ochiai A, Akimoto S, Shimoyama Y, et al. Frequent loss of alpha catenin expression in scirrhous carcinomas with scattered cell growth [Ｊ]. Jpn J Cancer Res, 1994; 85(3)∶266.
- 4. Aoki M, Hecht A, Kruse U, et al. Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoidenhancing factor 1 [Ｊ]. Proc Natl Acad Sci USA, 1999; 96(1)∶139.
- 5. Qiao Q, Ramadani M, Gansauge S, et al. Reduced membranous and ectopic cytoplasmic expression of betacatenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer [Ｊ]. Int J Cancer, 2001; 95(3)∶194.
- 6. Karayiannakis AJ, Nakopoulou L, Gakiopoulou H, et al. Expression patterns of betacatenin in in situ and invasive breast cancer [Ｊ]. Eur J Surg Oncol, 2001; 27(1)∶31.
