Prostaglandin E1 Protects Against IschemiaReperfusion Injury of the Rats Liver_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JI Degang ¹ , LIU Bingyi ¹ , ZHENG Zelin ¹ , WANG Wei ²

Department of Surgery, The Third Hospital of Jilin University, Changchun 130031, China;

Corresponding author：

Keywords：

LiverI; schemia-reperfusion; Prostaglandin E1; Endothelin-1; Tumor necrosis factor-α

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ObjectiveTo investigate the protective mechanism of prostaglandin E1 against hepatic ischemia reperfusion injury.MethodsUsing 45minute ischemiareperfusion rat model in normal temperature, PGE1 was injected into portal vein before ischemia. An hour later blood was taken from portal vein to examine the enzyme levels, including GOT, GPT, LDH and TNFα, ET1. The alteration of pathological morphology of the ischemia lobe was observed.ResultsThe three enzemes, TNFα, ET1 levels of ischemiareperfusion group were significantly higher than those of the control group (P＜0.01). The indices of the PGE1 group were much lower than those of the ischemiareperfusion group (P＜0.01), but little higher than those of the control group (P＞0.05). The control group had obvious alteration in pathological morphology, but only slight alteration in PGE1 group, compared with the control group. ConclusionPGE1 protects against ischemiareperfusion injury of the liver.

Citation： JI Degang,LIU Bingyi,ZHENG Zelin,WANG Wei. Prostaglandin E1 Protects Against IschemiaReperfusion Injury of the Rats Liver. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(1): 36-38. doi: Copy

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2. 王志伟,黄宇琦.肝脏缺血再灌注损伤 [Ｊ]. 中国普外基础与临床杂志, 1998; 5（4）∶253.
3. 汤礼军.肝脏缺血再灌注损伤介质的研究现状 [Ｊ]. 肝胆外科杂志, 1998; 6（2）∶318.
4. Ishikawa T, Yamamoto Y, Takeuchi K. Relationship between peri and postoperative plasma concentration of endothelin1 and liver dysfunction in rat liver transplantation [Ｊ]. Transplant Proc, 1995; 27（1）∶524.
5. Natori S, Fujii Y, Kurosawa H, et al. Prostaglandine E1 protects against ischemiareperfusion injury of the liver by inhibition of neutrophil adherence to endothelial cells [Ｊ]. Transplantation, 1997; 64（11）∶1514.
6. 贾因堂,王守义,解中坚.前列腺素E1对肿瘤坏死因子水平及磷脂酶A2活性的影响 [Ｊ]. 中华肝病杂志, 1997； 5（3）∶172.
7. Xu HS, Rosenlof LK, Rruett TL, et al. Prostaglandin E1 increases survival with extended anhepatic phase during liver transplantation [Ｊ]. Ann Surg, 1994; 220（1）∶53.
8. Greig PD, Woolf GM, Sinclair SB, et al. Treatment of primary liver graft nonfunction with prostaglandin E1 [Ｊ]. Transplantation, 1989; 48（3）∶447.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Prostaglandin E1 Protects Against IschemiaReperfusion Injury of the Rats Liver

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