• Department of General Surgery, The First Affiliated Hospital of Sun Yatsen University of Medical Sciences, Guangzhou 510080,China;
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ObjectiveTo study the expression of p27 in hepatocellular carcinoma (HCC) and its clinical significance.MethodsFortyfive specimens of HCC and 30 specimens of adjacent noncancerous lesions obtained from 45 patients who underwent surgery were examined for p27 expression by immunohistochemistry SABC method. The diameter of tumor ranged from 1 cm to 19 cm (d ≤5 cm, 9 samples; 5 cm lt;d≤10 cm, 19 samples; d>10 cm, 17 samples). These tumors were graded according to the criteria described by EdmondsonSteiner: highdifferentiated HCC group (Grade Ⅰ+Ⅱ), 26 samples; lowdifferentiated HCC group (Grade Ⅲ+Ⅳ), 19 samples. According to the clinicopathological features: 19 samples were poorly encapsulated, 15 samples had portal invasion, 11 samples had extrahepatic metastasis, 12 samples had intrahepatic metastasis; all of the above were classified as the invasive and metastatic group, while the others were classified as the noninvasive and nonmetastatic group. ResultsThe average labeling index (LI) of p27 in HCC was significantly higher than that of adjacent noncancerous lesions (45.87±14.21 vs 33.77±12.92, P lt;0.001). The LI of p27 in lowdifferentiated HCC group (stage Ⅲ+Ⅳ) was significantly lower than that of highdifferentiated group (stage Ⅰ+Ⅱ), 34.46±12.29 vs 52.80±11.36 (P lt;0.001). The LI of p27 had significant difference between the large ones (d>10 cm, 37.59±13.12) and the small ones (d≤5 cm, 53.28±15.17 or 5 cm lt;d≤10 cm, 49.50±10.96) (P lt;0.05). The LI of p27 in the invasive and metastatic group was significantly lower than that in the noninvasive and nonmetastatic group (41.42±12.86 vs 51.44±14.10, P lt;0.05).ConclusionThe expression of p27 is more frequently detected in HCC than in adjacent noncancerous lesions. It indicates that p27 might be a compensatory factor during HCC carcinogenesis. The LI of p27 significantly decreases in poor differentiation group, invasive and metastatic group. It indicates that p27 might be related with the differentiation, invasion and metastasis of HCC.

Citation: ZHOU Qi,WANG Guangtian,LIANG Lijian,ZHENG Wei,PANG Zhigang. Expression of p27 in Hepatocellular Carcinoma and Its Clinical Significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(2): 134-136. doi: Copy

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