The Expression of Vascular Endothelial Growth Factor and Proliferating Cell Nuclear Antigen and Its Clinical Significance in Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Guokai ¹ , LUO Kaiyuan ² , WU Bin ¹ , SHI De ¹

Department of Vascular Surgery，The First Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400016, China;

Corresponding author：

Keywords：

Colorectal cancer; Vascular endothelial growth factor; Proliferating cell nuclear antigen

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo investigate the expression of vascular endothelial growth factor （VEGF） and proliferating cell nuclear antigen (PCNA) in colorectal cancer and its relationship with metastasis and recurrence. MethodsParaffinembedded specimens from 59 patients with colorectal cancer, 16 patients with adenomas and 12 normal colonic tissues were examined and compared by SP immunohistochemical method. ResultsThe positive rate of VEGF in colorectal cancer were significantly higher than that in adenomas (P＜0.05). The positive rate of VEGF in Dukes A and B stage of colorectal cancer were significantly higher than those in Dukes C and D (P＜0.05). Expression of VEGF in postoperative recurrence group was markedly higher than that in the group with no recurrence (P＜0.05). Proliferative activity expression suggested that the poorer the differentiation, the more PCNA increased in case of lymphnode or hepatic metastasis. The PCNA showed marked difference between postoperative and nonpostoperative recurrences (P＜0.05). Conclusion The expression of VEGF and PCNA is closely related to the invasion and metastasis of tumor during the operation. The increased VEGF and high PCNA implies that there may be some potential metastasis present.

Citation： YANG Guokai,LUO Kaiyuan,WU Bin,SHI De. The Expression of Vascular Endothelial Growth Factor and Proliferating Cell Nuclear Antigen and Its Clinical Significance in Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(4): 376-378. doi: Copy

1.	蒋光愉，谢作煊. 大肠癌旁移行粘膜的增殖活性及其分布 [J]. 临床与实验病理学杂志， 1997； 13（3）∶212.
2.	Hamada J, Cavanaugh PG, Lotan O, et al. Separable growth and migration factors for largecell lymphoma cell secreted by microvascular endothelial cell derived from target organs for metastasis [J]. Br J Cancer, 1992； 66(2)∶349.
3.	Landriscina M, Cassano A, Ratto C, et al. Quantitative analysis of basic fibroblast growth factor and vascular endothelial growth factor in human colocrectal cancer [J]. Br J Cancer, 1998； 78(6)∶765.
4.	杨毅军，石景森. 血管内皮生长因子与肿瘤血管生成 [J]. 中国普外基础与临床杂志， 2001； 8（3）∶205.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Expression of Vascular Endothelial Growth Factor and Proliferating Cell Nuclear Antigen and Its Clinical Significance in Colorectal Cancer

Abstract Full text Figures/Tables Video References Cited by

Format

Content