Expression of 4 Kinds of TumorAssociated Antigen in Gallbladder Carcinomas and Its Clinical Significance_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YAN Xiaochu , YAN Fenqin , LIU Fengxuan , et al

Institute of Pathology, Southwest Hospital, The Third Military Medical University, Chongqing 400038;

Corresponding author：

Keywords：

Gallbladder carcinoma; Carcinoembryonic antigen; Ecadherin; Proliferating cell nuclear antigen; Prognosis

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Objective To explore the value of expression of carcinomaassociated antigens in early diagnosis and predicting prognosis in gallbladder carcinoma. MethodsThe expression of carcinoembryonic antigen (CEA), carbohydrate antigen (CA50), Ecadherin (ECD) and proliferating cell nuclear antigen (PCNA) in 10 cases of cholecystitis, 10 cases of gallbladder adenomas and 50 cases of gallbladder carcinomas were detected by immunohistochemistry. ResultsThe positive rate of CEA, CA50 and PCNA labeling index (LI) in gallbladder carcinomas were significantly higher than that of gallbladder adenomas and cholecystitis (P＜0.05 and P＜0.01). The positive rate of ECD in gallbladder carcinomas, especially with metastasis, was significantly lower than that of gallbladder adenomas and cholecystitis (P＜0.05). The 3year survival rate was significantly lower in gallbladder carcinomas with CEA and PCNA overexpression (P＜0.05), the 3year survival rate in patients with ECD positive tumors was higher than that of those with negative tumors (P＜0.05). Conclusion The detection of CEA, CA50 and PCNA is useful for early diagnosis of malignant change in gallbladder adenomas and gallbladder carcinomas. Therefore, the CEA, PCNA and ECD might be useful for predicting prognosis of gallbladder carcinomas.

Citation： YAN Xiaochu,YAN Fenqin,LIU Fengxuan,et al. Expression of 4 Kinds of TumorAssociated Antigen in Gallbladder Carcinomas and Its Clinical Significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(2): 80-82. doi: Copy

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1. Hidalgo GLA, Badia PJM, Heredia BA, et al. Natural history of gallbladder carcinoma: clinical and pathologic factors \[J\]. Rev Esp Enferm Dig, 1997； 89(3)∶186.
2. Roa I, Araya JC, Villaseca M, et al. Gallbladder cancer in a high risk area: morphological features and spread patterns \[J\]. Hepatogastroenterology, 1999; 46(27)∶1540.
3. Albores SJ, Henson DE, Sobin LH. The WHO histological classification of tumors of the gallbadder and extrahepatic bile ducts \[J\]. Cancer, 1992; 70(2)∶410.
4. 惠延平，黄高升，王文亮.ras、cerb B2癌基因蛋白在胃癌及其癌旁组织的表达及分布特征 \[J\]. 诊断病理学杂志，2001； 8（3）∶163.
5. Tanno S, Obara T, Fujii T, et al. Proliferative potential and Kras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union \[J\]. Cancer, 1998; 83(2)∶267.
6. Stefanovic D, Novakovic R, Perisic SM, et al. The evaluation of tumor markers levels in determination of surgical procedure in patients with gallbladder carcinoma \[J\]. Med Pregl, 1993; 46(Suppl 1)∶58.
7. Kawa S, Tokoo M, Hasebe O, et al. Comparative study of CA50 and CA242 for the diagnosis of pancreatic cancer \[J\]. Br J Cancer,1994; 70（3）∶481.
8. Sasatomi E, Tokunaga O, Miyazaki K, et al. Spontaneous apoptosis in gallbladder carcinoma. Relationships with clinicopathologic factors, expression of Ecadherin, bcl2 protooncogene, and p53 on cosuppressor gene \[J\]. Cancer, 1996; 78(10)∶2101.
9. 许元鸿，郭仁富，郭克建,等. 增殖细胞核抗原（PCNA）在原发性胆囊癌中的表达及其预后意义 \[J\]. 中华消化杂志，1998; 18（1）∶10.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of 4 Kinds of TumorAssociated Antigen in Gallbladder Carcinomas and Its Clinical Significance

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