可溶性P选择素可抑制多形核中性粒细胞通过整合素CD11b与血管内皮细胞粘附，有明显的控制炎症的作用［1］，也可介导某些肿瘤细胞与内皮细胞的粘附［2］，与肿瘤的发展和转移有关。为探讨血浆可溶性P选择素水平在乳腺癌患者手术前后的变化及意义，我们检测了42例乳腺癌患者手术前后血浆可溶性P选择素水平，现报道如下。
1资料与方法
正常对照组36例，男女各18例，年龄23~55岁，平均37.6岁，系健康体检者，于早晨取空腹静脉血。乳腺癌组42例，年龄27～68岁，平均47.6岁，均为临床Ⅱ期患者，并行根治性手术，其中行乳腺癌根治术15例，乳腺癌改良根治术27例。组织学类型： 单纯癌29例，浸润性导管癌5例，髓样癌3例，硬癌3例，粘液腺癌2例。分别于术前1 d、术后第1 d、15 d和30 d早晨取空腹静脉血，应用可溶性P选择素ELISA试剂盒（苏州医学院血栓病研究所提供）检测血浆可溶性P选择素。所得数据用±s表示，用t检验和方差分析进行组间比较。
Citation：
刘剑勇,高月芳,覃宇周,吴飞翔,张力图,唐朝晖,李挺,杨南武. 乳腺癌患者手术前后血浆可溶性P选择素的检测及意义△. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(2): 121-121. doi:
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