Development of LivingRelated Liver Transplantation for Children_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032;

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Keywords：

Children; Liver transplantation

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Objective To review the advances of livingrelated liver transplantation for children. MethodsOn the basis of the data in Kyoto university, the center of livingrelated liver transplantation in the world, the current situation of livingrelated liver transplantation for children were investigated. ResultsEighty percent of patients who underwent the livingrelated liver transplantation were children with cholestatic liver disease. From the data of 462 cases, the patients’survival rate for 1, 3 and 5 years after livingrelated liver transplantation (79.8%, 77.0% and 77.0% respectively) preceded the survival rate of 129 patients who underwent the whole liver transplantation (76.0%, 70.0% and 65.0% respectively). To the livingrelated liver transplantation, the survival rate was higher for patients who underwent selective operation (85.0%) than emergency surgery (67.0%). The principal causes of death were rejection and infection. Furthermore, a partial orthotopic liver transplantation and livingrelated liver replantation were performed for children. Conclusion Strict indication, optimal health status and perfect postoperative management are the keys to keep patients longterm healthy survival. The curative effect of livingrelated liver transplantation precedes the whole liver transplantation. For children, livingrelated liver transplantation is better than for adults.

Citation： GUAN Wenxian,LI Kaizong,DOU Kefeng.. Development of LivingRelated Liver Transplantation for Children. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(4): 282-284. doi: Copy

1.	Bismuth H, Houssin D. Reducedsized orthotopic liver graft in hepatic transplantation in children [J]. Surgery， 1984； 95（3）∶367.
2.	Raia S, Nery JR, Mies S. Liver transplantation from live donors [J]. Lancet， 1989； 2（8661）∶497.
3.	Strong RW, Lynch SV, Ong TH, et al. Successful liver transplantation from a living donor to her son [J]. N Engl J Med， 1990； 322（21）∶1505.
4.	Lerut JP,Ciccarelli O,Roggen FM et al．Adulttoadult living related liver transplantation: initial experience [J]. Acta Gastroenterol Belg， 2001； 64(1)∶9.
5.	Colle I，Van Vlierberghe H，Troisi R，et al.Living related adulttoadult liver transplantation: which patient should benefit from this technique? [J]. Acta Gastroenterol Belg， 2001； 64(1)∶6.
6.	Tatekawa Y，Asonuma K，Uemoto S，et al.Liver transplantation for biliary atresia associated with malignant hepatic tumors [J]. J Pediatr Surg， 2001； 36(3)∶436.
7.	Testa G，Malago M，Broelsch CE.From living related to insitu split liver transplantation: how to reduce waitinglist mortality [J]. Pediatr Transplant， 2001； 5(1)∶16.
8.	Kim YS，Moon JI，Jeong HJ，et al.Live donor renal allograft in endstage renal failure patients from immunoglobulin A nephropathy [J]. Transplantation， 2001； 71(2)∶233.
9.	Kasahara M，Ohwada S，Takeichi T，et al. Livingrelated liver transplantation for type Ⅱ citrullinemia using a graft from heterozygote donor [J]. Transplantation， 2001； 71(1)∶157.
10.	Muiesan P，Rela M，Heaton ND.Use of cadaveric superior mesenteric artery as interpositional vascular graft in orthotopic liver transplantation [J]. Br J Surg， 2001； 88(1)∶70.
11.	Cacciarelli TV, So SK, Lim J, et al. A reassessment of ABO incompatibility in pediatric liver transplantation [J]. Transplantation， 1995; 60(7)∶757.
12.	Farges O, Kalil AN, Samuel D, et al. The use of ABOincompatible grafts in liver transplantation: a lifesaving procedure in highly selected patients [J]. Transplantation， 1995； 59(8)∶1124.
13.	原崎秀雄，吉野浩之，水田耕一，他. 本邦における生体移植の集計 [J].外科，1999； 61(10)∶1101.
14.	猪股裕纪洋, 田中紘一. 生体肝移植治療の変遷 [J]. 医学のあゆみ, 1999; 190（11）∶1023.
15.	猪股裕纪洋, 尾池文隆, 上田幹子. 小児生体部分移植の成績 [J]. 外科, 1999; 61（10）∶1107.
16.	市田隆文.原発性胆汁性肝硬変に対する肝移植の適応と問題 [J]. 肝臓, 1998; 39（1）∶5.
17.	Tanaka K. 生体肝移植の现状と课题 [J]. 肝臓, 1997; 38(1)∶7.
18.	Bai X, Hosler G,Rogers BB,et al. Quantitative polymerase chain reaction for human herpesvirus diagnosis and measurement of EpsteinBarr virus burden in posttransplant lymphoproliferative disorder [J].Clin Chem,1997; 43（10）∶1843.
19.	Praghakaran K, Wise B, Chen A, et al. Rational management of posttransplant lymphoproliferative disorder in pediatric recipients [J]. J Pediatr Surg, 1999; 34（1）∶112.
20.	Gubernatis G，Pichlmayr R，Kemnitz J,et al． Auxiliary partial orthotopic liver transplantation(APOLT) for fulminant hepatic failure： first successful case report [J]． World J Surg,199l; 15（5）∶660.
21.	Bismuth H， Azoulay O，Samuel D, et al．Auxiliary partial orthotopic liver transplantation for fulminant hepatitis.The Paul Brousse experience [J]．Ann Surg,1996; 224（6）∶712.
22.	Egawa H，Tanaka K，Inomata Y, et al. Auxiliary partial orthotopic liver transplantation from a living related donor： two cases [J]． Transplant Proc，1996; 28（2）∶1071.
23.	Kasahara M，Kiuchi T， Uryuhara K, et al．Auxiliary partial orthotopic liver transplantation as a rescue for smallforsize grafts harvested from living donors [J]． Transplant Proc, 1998; 30（1）∶132.
24.	Kaibori M，Egawa H，Inomata Y, et al．Selective portal blood flow diversion in auxilary partial orthotopic liver transplantation to induce regeneration of the graft [J]． Transplantation, 1998; 66（7）∶935.
25.	肝移植研究会. 肝移植症例登録報告 [J]. 肝臓,1998; 39（1）∶5.
26.	猪股裕纪洋, 田中紘一, 阿蘇沼弘. 胆道閉锁症に対する肝移植の長期成績 [J] .小児外科，1999; 31（5）∶306.
27.	渕之上昌平. 肝移植における免疫抑制療法 [J]. 医学のあゆみ, 1999； 191(11)∶1076.

1. Bismuth H, Houssin D. Reducedsized orthotopic liver graft in hepatic transplantation in children [J]. Surgery， 1984； 95（3）∶367.
2. Raia S, Nery JR, Mies S. Liver transplantation from live donors [J]. Lancet， 1989； 2（8661）∶497.
3. Strong RW, Lynch SV, Ong TH, et al. Successful liver transplantation from a living donor to her son [J]. N Engl J Med， 1990； 322（21）∶1505.
4. Lerut JP,Ciccarelli O,Roggen FM et al．Adulttoadult living related liver transplantation: initial experience [J]. Acta Gastroenterol Belg， 2001； 64(1)∶9.
5. Colle I，Van Vlierberghe H，Troisi R，et al.Living related adulttoadult liver transplantation: which patient should benefit from this technique? [J]. Acta Gastroenterol Belg， 2001； 64(1)∶6.
6. Tatekawa Y，Asonuma K，Uemoto S，et al.Liver transplantation for biliary atresia associated with malignant hepatic tumors [J]. J Pediatr Surg， 2001； 36(3)∶436.
7. Testa G，Malago M，Broelsch CE.From living related to insitu split liver transplantation: how to reduce waitinglist mortality [J]. Pediatr Transplant， 2001； 5(1)∶16.
8. Kim YS，Moon JI，Jeong HJ，et al.Live donor renal allograft in endstage renal failure patients from immunoglobulin A nephropathy [J]. Transplantation， 2001； 71(2)∶233.
9. Kasahara M，Ohwada S，Takeichi T，et al. Livingrelated liver transplantation for type Ⅱ citrullinemia using a graft from heterozygote donor [J]. Transplantation， 2001； 71(1)∶157.
10. Muiesan P，Rela M，Heaton ND.Use of cadaveric superior mesenteric artery as interpositional vascular graft in orthotopic liver transplantation [J]. Br J Surg， 2001； 88(1)∶70.
11. Cacciarelli TV, So SK, Lim J, et al. A reassessment of ABO incompatibility in pediatric liver transplantation [J]. Transplantation， 1995; 60(7)∶757.
12. Farges O, Kalil AN, Samuel D, et al. The use of ABOincompatible grafts in liver transplantation: a lifesaving procedure in highly selected patients [J]. Transplantation， 1995； 59(8)∶1124.
13. 原崎秀雄，吉野浩之，水田耕一，他. 本邦における生体移植の集計 [J].外科，1999； 61(10)∶1101.
14. 猪股裕纪洋, 田中紘一. 生体肝移植治療の変遷 [J]. 医学のあゆみ, 1999; 190（11）∶1023.
15. 猪股裕纪洋, 尾池文隆, 上田幹子. 小児生体部分移植の成績 [J]. 外科, 1999; 61（10）∶1107.
16. 市田隆文.原発性胆汁性肝硬変に対する肝移植の適応と問題 [J]. 肝臓, 1998; 39（1）∶5.
17. Tanaka K. 生体肝移植の现状と课题 [J]. 肝臓, 1997; 38(1)∶7.
18. Bai X, Hosler G,Rogers BB,et al. Quantitative polymerase chain reaction for human herpesvirus diagnosis and measurement of EpsteinBarr virus burden in posttransplant lymphoproliferative disorder [J].Clin Chem,1997; 43（10）∶1843.
19. Praghakaran K, Wise B, Chen A, et al. Rational management of posttransplant lymphoproliferative disorder in pediatric recipients [J]. J Pediatr Surg, 1999; 34（1）∶112.
20. Gubernatis G，Pichlmayr R，Kemnitz J,et al． Auxiliary partial orthotopic liver transplantation(APOLT) for fulminant hepatic failure： first successful case report [J]． World J Surg,199l; 15（5）∶660.
21. Bismuth H， Azoulay O，Samuel D, et al．Auxiliary partial orthotopic liver transplantation for fulminant hepatitis.The Paul Brousse experience [J]．Ann Surg,1996; 224（6）∶712.
22. Egawa H，Tanaka K，Inomata Y, et al. Auxiliary partial orthotopic liver transplantation from a living related donor： two cases [J]． Transplant Proc，1996; 28（2）∶1071.
23. Kasahara M，Kiuchi T， Uryuhara K, et al．Auxiliary partial orthotopic liver transplantation as a rescue for smallforsize grafts harvested from living donors [J]． Transplant Proc, 1998; 30（1）∶132.
24. Kaibori M，Egawa H，Inomata Y, et al．Selective portal blood flow diversion in auxilary partial orthotopic liver transplantation to induce regeneration of the graft [J]． Transplantation, 1998; 66（7）∶935.
25. 肝移植研究会. 肝移植症例登録報告 [J]. 肝臓,1998; 39（1）∶5.
26. 猪股裕纪洋, 田中紘一, 阿蘇沼弘. 胆道閉锁症に対する肝移植の長期成績 [J] .小児外科，1999; 31（5）∶306.
27. 渕之上昌平. 肝移植における免疫抑制療法 [J]. 医学のあゆみ, 1999； 191(11)∶1076.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Development of LivingRelated Liver Transplantation for Children

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