Expression of Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in Hepatocellular Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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The Laboratory of Surgical Department, West China Hospital, Sichuan University, Chengdu 610041;

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Hepatocellular carcinoma Vascular endothelial growth factor Matrix metalloproteinase-9

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ObjectiveTo investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase9 (MMP9) and the recurrence or metastasis of hepatocellular carcinoma (HCC).MethodsThe expression of VEGF and MMP9 in 50 HCC tissues and in 30 normal liver tissues were examined by immunochemistry.ResultsThe positive rates of VEGF and MMP9 in HCC tissue were 86% and 68% respectively, and 53.3% and 33.3% respectively in normal liver tissue. The positive rates of VEGF and normal liver tissue (P lt;0.05). The correlation between expressions of MMP9 and VEGF was very significant (r=0.98，P lt;0.01). The positive rates of VEGF and MMP9 in HCC with metastasis were higher than that of HCC without metastasis.ConclusionVEGF and MMP9 are expressed cooperatively. Both of them play important role in the invasion and metastasis of HCC.

Citation： LIU Zhimin,YAN Lnan,TANG Yu,et al.. Expression of Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in Hepatocellular Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(6): 421-423. doi: Copy

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1. 杨毅军，石景森. 血管内皮生长因子与肿瘤血管生成 [J]. 中国普外基础与临床杂志，2001； 8（3）∶205.
2. Salven P, Heikkil A, Joensuu H. Enhanced expression of vascular endothelial growth factor in metastatic melanoma [J]. Br J Cancer,1997; 76(7)∶930.
3. 王晓东，杨金巧. 乳腺癌基质金属蛋白酶的表达及其意义 [J]. 中国普外基础与临床杂志，2000； 7（5）∶341.
4. Curran S, Murray GI. Matrix metalloproteinases in tumour invasion and metastasis [J]. J Pathol,1999; 189(3)∶300.
5. Arii S, Tanaka J, Yamazoe Y, et al. Predictive factors for intrahepatical recurrence of hepatocelluar carcinoma after partial hepatectomy [J]. Cancer,1992; 69(4)∶ 913.
6. Moses M, Sudhalter J, Lange R, et al. Identification of an inhibitor of neovascularization from cartilage [J]. Science, 1990; 248(4961)∶1408.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in Hepatocellular Carcinoma

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