Objective To observe the changes of basement membrane (BM) during carcinogenic change of the atypical hyperplasia of the mammary.
Methods SP immunohistochemical method and two special stain method (Foot and PAS stain method) and the electron microscope were used to observe the changes of the BM.
Results BM already changed in atypical hyperplasia grade Ⅱ, and more significantly changed in atypical hyperplasia grade Ⅲ. BM was thinner or thicker somewhere distinctively under the microscope, and some little deletions were observed under the electron microscope in atypical hyperplasia grade Ⅲ, and there was no BM in breast cancer.
Conclusion The change procedure of BM was correlated with the changes of the epithelial, atypical hyperplasia. The changes of BM in the atypical hyperplasia are a part of the carcinogenic procedure from the epithelial atypical hyperplasia of the mammary.
Citation：
HAN Xiaorong,JIANG Jun,MA Hongmin.. CHANGES OF BASEMENT MEMBRANE DURING CARCINOGENIC CHANGE OF THE ATYPICAL HYPERPLASIA OF THE MAMMARY.. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(2): 75-77. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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- 3. Weaver VM, Fischer AH, Peterson OW, et al. The importance of the microenvironment in breast cancer progression:recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a threedimensional culture assay [J]. Biochem Cell Biol, 1996; 74(6)∶833.
- 4. Liotta A. Cancer cell invasion and metastasis [J]. Scientific Am, 1992; 266(2)∶34.
- 5. Werb Z, Ashkenas J, MacAuley A. et al. Extracellular matrix remodeling as a regulator of stromalepithelial interactions during mammary gland development, involution and carcinogenesis [J]. Braz J Med Biol Res, 1996; 29(9)∶1087.
- 6. Madan AK, Yu K, Dhurandhar N, et al. Association of hyaluronidase and breast adenocarcinoma invasiveness [J]. Oncol Rep 1999; 6(3)∶607.
- 7. 姜军，詹新恩，陈意生等.乳腺上皮不典型增生时DNA含量、超微结构及肿瘤相关抗原变化的意义 [J].中国普外基础与临床杂志，1998； 5(4)∶208.
- 8. Flug M, Kopf Maier P. The basement membrane and its involvement in carcinoma cell invasion [J]. Acta Anat Bassel, 1995; 152(2)∶69.
