CLINICAL STUDY ON THE ALLIED CHEMOTHERAPY WITH 5-Fu、LEUCOVORIN AND LEVAMISOLE AFTER COLORECTAL CANCER SURGERY_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Department of General Surgery,The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041;

Corresponding author：

Keywords：

Colorectal cancer Chemotherapy 5-Fluorouracil Leucovorin Levamisole

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the effect of the allied chemotherapy with 5-Fu、leucovorin (CF) and levamisole (LV) after resection of colorectal cancer.
Methods 242 cases were divided randomly into three groups. 80 cases (group Ⅰ) were treated with 5-Fu and CF. 80 cases(groupⅡ) were treated with 5-Fu and LV. 82 cases (group Ⅲ) were treated with 5-Fu、CF and LV. Results The recurrence rates of group Ⅲ was 12.20%, which was significantly lower than that of group Ⅰ (26.25%) and group Ⅱ(27.50%). (P＜0.05). The 5-year survival rates in group Ⅰ, group Ⅱ and group Ⅲ were 37.50%, 35.00% and 58.54%, respectively, the highest one was in Group Ⅲ (P＜0.01).
Conclusion The allied chemotherapy with 5-Fu、CF and LV is an effective therapy for petients of colorectal cancer after surgery, which can significantly decrease the recurrence and improve the 5-year survival rate.

Citation： ZHUANG Chaoping,SHEN Wenl,WU Junwei,et al.. CLINICAL STUDY ON THE ALLIED CHEMOTHERAPY WITH 5-Fu、LEUCOVORIN AND LEVAMISOLE AFTER COLORECTAL CANCER SURGERY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(3): 164-165. doi: Copy

1.	Grem JL, Hoth DF, Hamilton JM, et al. Overview of current status and future direction of clinical trials with 5fluorouracil in comlination with folinic alid 〔J〕. Cancer Treat Rep, 1987； 71(8)∶1249.
2.	Ehrlichman C, Fine S, Wong A, et al. A comparison of 5fluorouracil and folinic acid versus 5Fu in metastatic colorectal cancer 〔J〕. Proc Am Soc Clin, 1986； 5(2)∶82.
3.	管忠震，何友兼，刘茂珍等.大剂量荃醛氢叶酸合并氟脲嘧啶〔HDCF/5Fu〕治疗晚期胃肠道癌的探讨〔J〕.癌症，1989; 8(6)∶421.
4.	Guyatt G, Mitchell A. Advanced Colorectal Cancer MeraAnalysis Project. Modutation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate 〔J〕. J Clin Onw, 1992； 10(6)∶625.
5.	郑秀立，潘良熹，黄富麟等.高低剂量醛氢叶酸合并氟脲嘧啶治疗晚期胃肠道癌〔J〕.肿瘤防治研究，1994； 21(5)∶323.
6.	Moertel CG. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma 〔J〕. New Engl J Med, 1990； 322(4)∶352.
7.	Grem JL. Current treatment approaches in colorectal cancer 〔J〕. Sem Oncaal, 1991； 18(Suppl 1)∶17.
8.	吴阶平，裘法祖主编.黄家驷外科学〔M〕.第5版. 北京：人民卫生出版社，1992∶1288～1289.

1. Grem JL, Hoth DF, Hamilton JM, et al. Overview of current status and future direction of clinical trials with 5fluorouracil in comlination with folinic alid 〔J〕. Cancer Treat Rep, 1987； 71(8)∶1249.
2. Ehrlichman C, Fine S, Wong A, et al. A comparison of 5fluorouracil and folinic acid versus 5Fu in metastatic colorectal cancer 〔J〕. Proc Am Soc Clin, 1986； 5(2)∶82.
3. 管忠震，何友兼，刘茂珍等.大剂量荃醛氢叶酸合并氟脲嘧啶〔HDCF/5Fu〕治疗晚期胃肠道癌的探讨〔J〕.癌症，1989; 8(6)∶421.
4. Guyatt G, Mitchell A. Advanced Colorectal Cancer MeraAnalysis Project. Modutation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate 〔J〕. J Clin Onw, 1992； 10(6)∶625.
5. 郑秀立，潘良熹，黄富麟等.高低剂量醛氢叶酸合并氟脲嘧啶治疗晚期胃肠道癌〔J〕.肿瘤防治研究，1994； 21(5)∶323.
6. Moertel CG. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma 〔J〕. New Engl J Med, 1990； 322(4)∶352.
7. Grem JL. Current treatment approaches in colorectal cancer 〔J〕. Sem Oncaal, 1991； 18(Suppl 1)∶17.
8. 吴阶平，裘法祖主编.黄家驷外科学〔M〕.第5版. 北京：人民卫生出版社，1992∶1288～1289.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

CLINICAL STUDY ON THE ALLIED CHEMOTHERAPY WITH 5-Fu、LEUCOVORIN AND LEVAMISOLE AFTER COLORECTAL CANCER SURGERY

Abstract Full text Figures/Tables Video References Cited by

Format

Content