STUDY ON THE CHANGE OF PLASMA ENDOTHELIN,LPS,TNF-α,IL-6 AND IL-8 IN PATIENTS WITH OBSTRUCTIVE JAUNDICE AFTER SURGERY_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, The First Affiliated Hospital, West China University of Medical Science, Chengdu 610041;

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Keywords：

Lip polysaccharide Endothelin Cytokine Obstructive jaundice

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Objective To research the changes in plasma endothelin, LPS, TNF-α, IL-6 and IL-8 in the patients with obstructive jaundice (OJ) and non-obstructive jaundice (NOJ) after surgery.
Methods The plasma ET, LPS, TNF-α, IL-6 and IL-8 were measured in 15 patients without jaundice as controls.
Results As compared with NOJ, the postoperative changes of ET, LPS, TNF-α, IL-6 and IL-8 in OJ group increased significantly at multiple time points (P＜0.05).
Conclusion There is interaction between ET,LPS, TNF-α, IL-6 and IL-8 and damage to multiple organ function in patients with OJ after surgery.

Citation： PENG Bing,WU Yantao,WANG Xiangdong,et al.. STUDY ON THE CHANGE OF PLASMA ENDOTHELIN,LPS,TNF-α,IL-6 AND IL-8 IN PATIENTS WITH OBSTRUCTIVE JAUNDICE AFTER SURGERY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(4): 245-246. doi: Copy

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1. 王齐欣, 陆玮, 林善琰. 内皮素与肝肾综合症〔Ｊ〕. 国外医学消化系统疾病分册, 1998; 18(2)∶103.
2. Grave J, Gouma D, Buuramn W. Complications in obstructive jaundice: role of endotoxins 〔Ｊ〕. Scand J Gastroenterol, 1992; 194(Suppl)∶8.
3. ScottConner CE, Grogan JB. The path physiology of biliary obstruction and its effect on phagocytic and immune function 〔Ｊ〕. J Surg Res, 1994; 57(2)∶316.
4. Sheron N, Lan JYN, Hofman J, et al. Dose dependent increase in plasma interleukin6 after recombinant tumor necrosis factor infusion in humans 〔Ｊ〕. Clin Exp Immunol, 1990; 82（3）∶427.
5. O’Nail S, Hunt J, Filkins J, et al. Obstruction jaundice in rats results in exaggerated hepatic production of TNFα and systemic and tissue TNFα and systemic and tissue TNFα levels after endotoxin 〔Ｊ〕. Surgery, 1997; 122(2)∶281.
6. Jones A, Selbx P, Viner C, et al. Tumor necrosis factor cholestatic jaundice and chronic liver disease 〔Ｊ〕. Gut, 1992; 31（8）∶938.
7. 蔺小红, 席宏丽, 斯崇文. 肝硬化并发自发性细菌性腹膜炎患者腹水中TNFα及IL6的测定及其意义〔Ｊ〕. 北京医科大学学报, 1999; 31(3)∶285.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

STUDY ON THE CHANGE OF PLASMA ENDOTHELIN,LPS,TNF-α,IL-6 AND IL-8 IN PATIENTS WITH OBSTRUCTIVE JAUNDICE AFTER SURGERY

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