ADVANCES IN IMMUNOGENE THERAPY OF MALIGNANT TUMOR_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

QUAN Yi , YAN Lnan.

Department of General Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041;

Corresponding author：

Keywords：

Malignant tumor Immunogene therapy

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Objective To study the effect of immunogene therapy on the improvement of the outcome of malignant tumor. Methods Literatures about immunogene therapy of malignant tumor were collected and reviewed.
Results The major methods of immunogene therapy of malignant tumor were as follows： ①Transference of cytokin genes into lymphocytes. ②Genetically engineered autologous tumor cells used as vaccine. ③Combined gene therapy.
Conclusion The therapeutic effect of malignant tumor can be improved by immunogene therapy.

Citation： QUAN Yi,YAN Lnan.. ADVANCES IN IMMUNOGENE THERAPY OF MALIGNANT TUMOR. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(4): 282-284. doi: Copy

1.	Malkovska V, Sondel PM, Malkovsky M. Tumor immunotherapy 〔Ｊ〕. Curr Opin Immunol, 1989; 1(2)∶883.
2.	Rosenberg SA, Michael T, Lotze MT, et al. A progrom report on the treatment of 157 patients with advanced cancer using lymphokineactived killer cells and IL2 alone 〔Ｊ〕. N Engl J Med, 1987; 316(5)∶889.
3.	Forni G, Cavallo GP, Giovarelli M, et al. Tumor immunotherapy by local injection of IL2 and nonreactive lymphocytes. Experimental and clinical results 〔Ｊ〕. Prog Exp Tumor Res, 1988; 32(1)∶187.
4.	Rosenberg SA, Power LB, Noonan KE, et al. Gene transfer into human immunotherapy of patient with advanced meianoma using tumor TIL modified by retroviral gene transduction 〔Ｊ〕. N Engl J Med, 1990; 323(10)∶570.
5.	Anderson C. Gene therapy research under fire over controversial cancer trail 〔Ｊ〕.Nature, 1992; 360(6403)∶399.
6.	Rosenberg SA, Puyal C, Felgner PL, et al. The immunotherapy and gene therapy of cancer 〔Ｊ〕. J Clin Oncol, 1992; 10(2)∶180.
7.	Roth SA, Cristiano RJ. Gene therapy for cancer: What have we done and where are we going 〔Ｊ〕? J Nat Can Inst, 1997; 89(1)∶21.
8.	Guenther G, Connid F, Anna G, et al. Retroviral vectormediated lymphokine gene transfer into human renal cancer cells 〔Ｊ〕. Cancer Research, 1992; 52(22)∶6229.
9.	Thara H, Sandgren EP, Quaife CJ, et al. Antitumor effects of IL12: application for the immunotherapy and gene therapy of cancer 〔Ｊ〕. Ther Gene, 1995; 2(2)∶96.
10.	Miller AR, Reters WT, Posner M, et al. Cytokine mediated gene therapy for cancer 〔Ｊ〕. Am Surg Oncol, 1994; 1(5)∶436.
11.	Sobol RE, Dinman JD, Icho T, et al. IL2 gene therapy in a patient with glioblastoma 〔Ｊ〕. Gene Ther, 1995; 2(2)∶164.
12.	Hui K, Grosveld F, Festenstein H, et al. Rejective of transplantable AKP leukaemia cells following MHC DNAmediated cell transformation 〔Ｊ〕. Nature, 1984; 311(6010)∶750.
13.	James RF, Edwards S, Hui RM, et al. The effect of class 2 gene transfection on the tumorigenicity of the H2knegative mouse leukaemia cell line K36.16 〔Ｊ〕. Immunology, 1991; 72(2)∶213.
14.	Nabel GJ, Nabel EJ, Yang ZY, et al. Direct gene transfer with DNAlipsome complex in melanoma: expression, biologic activity, and lack of toxicity in humans 〔Ｊ〕. Proc Natl Acad Sci USA, 1993; 90(6)∶11306.
15.	Sanda MG, Restifo NP, Walsh JC, et al. Molecular characterization of defective antigen processing in human prostate cancer 〔Ｊ〕. J Natl Cancer Inst, 1995; 87(1)∶280.
16.	Schwann RN. Costimulation of T lymphocytes: the role of CD28, CTL4 and B7/BB1 in IL2 production and immunotherapy 〔Ｊ〕. Cell, 1992; 71(7)∶1065.
17.	Chen L. Manipulation of T cell response to tumor by targeting on costimnlatory pathway 〔Ｊ〕. Leukemia, 1997; 11(3)∶567.
18.	Geldhof AB, Geert R, Marleen B, et al. Expression of B71 Highly metastatic mouse T lymphomas induces optimol natural killer cellmediated cytotoxicity 〔Ｊ〕. Cancer Res, 1995; 55(13)∶2730.
19.	Fenton RT, Bate SE, Sonnevel T, et al. A phase I trial of B7transfected or parental lethally irradiated allogeneic melanoma cell lines to induce cellmediated immunity against tumorassociated antigen presented by HLA A2 or HLAA1 in patients with stage IV melanoma 〔Ｊ〕. Human Gene Therapy, 1995; 6(1)∶87.
20.	Patel RL, Andre L, Richard D, et al. Cancer gene therapy annual conference 1997 〔Ｊ〕. Human Gene Therapy, 1998; 9(2)∶283.
21.	Chen L, Thomas EK, Hus L, et al. Human papilloma virus type 16 nucleoprotien E7 is a tumor rejection antigen 〔Ｊ〕. Proc Natl Ad Sci USA, 1991; 88(1)∶110.
22.	王洪平，吴易元. CD1：第三类抗原递呈分子〔Ｊ〕. 国外医学分子生物学分册， 1997； 19（2）∶75.
23.	DiMaio JM, Clary BM, Via DF, et al . Directed enzyme prodrug gene therapy for pantreatic cancer in vivo 〔Ｊ〕. Surgery, 1994； 116(2)∶205.
24.	Thomas F, Gajewski R, Jean C,et al. Costimulation with B71, IL6, and IL12 is sufficient for primary generation of murine antitumor cytotoxic T lymphocytes in vivo 〔Ｊ〕. J Immunnol, 1995; 154(11)∶5637.

1. Malkovska V, Sondel PM, Malkovsky M. Tumor immunotherapy 〔Ｊ〕. Curr Opin Immunol, 1989; 1(2)∶883.
2. Rosenberg SA, Michael T, Lotze MT, et al. A progrom report on the treatment of 157 patients with advanced cancer using lymphokineactived killer cells and IL2 alone 〔Ｊ〕. N Engl J Med, 1987; 316(5)∶889.
3. Forni G, Cavallo GP, Giovarelli M, et al. Tumor immunotherapy by local injection of IL2 and nonreactive lymphocytes. Experimental and clinical results 〔Ｊ〕. Prog Exp Tumor Res, 1988; 32(1)∶187.
4. Rosenberg SA, Power LB, Noonan KE, et al. Gene transfer into human immunotherapy of patient with advanced meianoma using tumor TIL modified by retroviral gene transduction 〔Ｊ〕. N Engl J Med, 1990; 323(10)∶570.
5. Anderson C. Gene therapy research under fire over controversial cancer trail 〔Ｊ〕.Nature, 1992; 360(6403)∶399.
6. Rosenberg SA, Puyal C, Felgner PL, et al. The immunotherapy and gene therapy of cancer 〔Ｊ〕. J Clin Oncol, 1992; 10(2)∶180.
7. Roth SA, Cristiano RJ. Gene therapy for cancer: What have we done and where are we going 〔Ｊ〕? J Nat Can Inst, 1997; 89(1)∶21.
8. Guenther G, Connid F, Anna G, et al. Retroviral vectormediated lymphokine gene transfer into human renal cancer cells 〔Ｊ〕. Cancer Research, 1992; 52(22)∶6229.
9. Thara H, Sandgren EP, Quaife CJ, et al. Antitumor effects of IL12: application for the immunotherapy and gene therapy of cancer 〔Ｊ〕. Ther Gene, 1995; 2(2)∶96.
10. Miller AR, Reters WT, Posner M, et al. Cytokine mediated gene therapy for cancer 〔Ｊ〕. Am Surg Oncol, 1994; 1(5)∶436.
11. Sobol RE, Dinman JD, Icho T, et al. IL2 gene therapy in a patient with glioblastoma 〔Ｊ〕. Gene Ther, 1995; 2(2)∶164.
12. Hui K, Grosveld F, Festenstein H, et al. Rejective of transplantable AKP leukaemia cells following MHC DNAmediated cell transformation 〔Ｊ〕. Nature, 1984; 311(6010)∶750.
13. James RF, Edwards S, Hui RM, et al. The effect of class 2 gene transfection on the tumorigenicity of the H2knegative mouse leukaemia cell line K36.16 〔Ｊ〕. Immunology, 1991; 72(2)∶213.
14. Nabel GJ, Nabel EJ, Yang ZY, et al. Direct gene transfer with DNAlipsome complex in melanoma: expression, biologic activity, and lack of toxicity in humans 〔Ｊ〕. Proc Natl Acad Sci USA, 1993; 90(6)∶11306.
15. Sanda MG, Restifo NP, Walsh JC, et al. Molecular characterization of defective antigen processing in human prostate cancer 〔Ｊ〕. J Natl Cancer Inst, 1995; 87(1)∶280.
16. Schwann RN. Costimulation of T lymphocytes: the role of CD28, CTL4 and B7/BB1 in IL2 production and immunotherapy 〔Ｊ〕. Cell, 1992; 71(7)∶1065.
17. Chen L. Manipulation of T cell response to tumor by targeting on costimnlatory pathway 〔Ｊ〕. Leukemia, 1997; 11(3)∶567.
18. Geldhof AB, Geert R, Marleen B, et al. Expression of B71 Highly metastatic mouse T lymphomas induces optimol natural killer cellmediated cytotoxicity 〔Ｊ〕. Cancer Res, 1995; 55(13)∶2730.
19. Fenton RT, Bate SE, Sonnevel T, et al. A phase I trial of B7transfected or parental lethally irradiated allogeneic melanoma cell lines to induce cellmediated immunity against tumorassociated antigen presented by HLA A2 or HLAA1 in patients with stage IV melanoma 〔Ｊ〕. Human Gene Therapy, 1995; 6(1)∶87.
20. Patel RL, Andre L, Richard D, et al. Cancer gene therapy annual conference 1997 〔Ｊ〕. Human Gene Therapy, 1998; 9(2)∶283.
21. Chen L, Thomas EK, Hus L, et al. Human papilloma virus type 16 nucleoprotien E7 is a tumor rejection antigen 〔Ｊ〕. Proc Natl Ad Sci USA, 1991; 88(1)∶110.
22. 王洪平，吴易元. CD1：第三类抗原递呈分子〔Ｊ〕. 国外医学分子生物学分册， 1997； 19（2）∶75.
23. DiMaio JM, Clary BM, Via DF, et al . Directed enzyme prodrug gene therapy for pantreatic cancer in vivo 〔Ｊ〕. Surgery, 1994； 116(2)∶205.
24. Thomas F, Gajewski R, Jean C,et al. Costimulation with B71, IL6, and IL12 is sufficient for primary generation of murine antitumor cytotoxic T lymphocytes in vivo 〔Ｊ〕. J Immunnol, 1995; 154(11)∶5637.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

ADVANCES IN IMMUNOGENE THERAPY OF MALIGNANT TUMOR

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