【Abstract】Objective To evaluate the status of vascular endothelial growth factor (VEGF) expression in breast carcinoma and benign disease and define the relationship with age,menopause, tumor size，clinical stage，distant metastasis and lymph node metastasis. Methods Seventy cases of invasive ductal breast carcinomas,30 benign breast diseases and 7 adjacent nonneoplastic specimens were assessed for VEGF protein expression by immunohistochemistry LSAB method. Results VEGF were expressed more frequently in breast cancer than in benign diseases.VEGF was significantly correlated with axillary lymph node metastasis and distant metastasis,whereas no statistical correlation with other factors. Conclusion VEGF status has certain value to make differential diagnosis between malignant and benign breast diseases and predict the possibilities of distant and lymph node metastasis.
Citation：
JING Jing,LI Hongjiang,ZHU Weiwei,et al.. EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN BREAST DISEASES AND ITS IMPLICATION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 322-323. doi:
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- 1. Lichtenbeld HC,Barendsz JAF,Van EN.Angigenic potential of malignant and nonmalignant human breast tissues an in vivo angiogenesis model 〔Ｊ〕. Int J Cancer,1998; 77(4)∶445.
- 2. Gruinelbretieve JM,Monique G,Gavoille A,et al.angiogenesis and risk of breast cancer in women with fibrocystic disease 〔Ｊ〕. J Natl Cancer Inst,1994; 86(8)∶635.
- 3. Grurid AJ,Fisher L,Harris JR.Microvessel density and distribution in ductal carcinoma in situ of the breast 〔Ｊ〕. J Natl Cancer Inst,1994; 86(8)∶614.
- 4. Jensen HM,Chen L,Devault MR.Angiogenesis induced by normal human breast tissue.A probable marker for precancer 〔Ｊ〕. Science,1982; 218(4569)∶293.
- 5. Wang G,Dong Z,Xu G,et al.The effect of antibody against vascular endothelial growth factor on tumor growth and metastasis 〔Ｊ〕. J Cancer Res Clin Oncol,1998; 124(11)∶615.
- 6. Brown L,Berse B,Jackman R.Expression of VPF/VEGF and its receptor in breast cancer 〔Ｊ〕. Hum Pathol,1995； 26(1)∶86.
- 7. Kurebayashi J, Otsuki T, Kumisue H. Expression of vascular endothelial growth factor (VEGF) family members in breast cancer 〔Ｊ〕. Jpn J Cancer Res,1999; 90(9)∶977.
