EFFECT OF 40% UREA SOLUTION ON THE ISCHEMIA OF LEFT PANCREAS LOBE IN DOG_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Hepatobiliary Surgery, People’s Hospital of Shanxi Province, Xi’an 710068;

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Animal model Pancreas Pathology

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【Abstract】Objective To investigate the effect of ischemia on the treatment of advanced body and tail carcinoma of pancreas. Methods In operation the proximal spleen artery was ligated, a chemotherapy pump was installed to connect the distal spleenic artery and urea solution (40%) was injected through the device during and after operation. The pathology and pathophysiology change in dogs were observed. Results All the eight dogs studied were alive after operation, no serious complication appeared, pancreatic cells were replaced by fibrosis. Conclusion Infusion of 40% urea solution is a safe and effective ischemic method, it can lead to all sorts of pancreatic cell necrosis and fibrosis. It may be a good madality in the treatment of advanced pancreatic carcinoma.

Citation： XIANG Guoan,GENG Zhimin,SUN Shuiping,et al.. EFFECT OF 40% UREA SOLUTION ON THE ISCHEMIA OF LEFT PANCREAS LOBE IN DOG. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(6): 373-374. doi: Copy

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1. Dalton RR, Sarr MG, Van Heerden JA, et al. Carcinoma of the body and tail of the pancreas: is curative resection justified 〔Ｊ〕. Surgery, 1992; 111（2）∶ 489.
2. 向国安, 秦兆寅,王西京等. 犬胰腺缺血模型的建立及意义〔Ｊ〕. 陕西医学杂志, 1999; 28(6)∶345.
3. Norback IH, Hruban RH, Roitnott JK, et al. Carcinoma of the body and tail of the pancreas 〔Ｊ〕. Am J Surg, 1992; 164（8）∶26.
4. Khoursheed M, Harvey C, Gould A. Embolization in the pallcation of complications of inoperable primary pancreatic neoplasms 〔Ｊ〕. Clinical R Dilogy, 1994; 49（11)∶ 784.
5. 向国安, 耿智敏, 秦兆寅等. 犬胰腺左叶缺血模型的建立及意义〔Ｊ〕. 西安医科大学学报, 2001; 21(5)∶446.
6. 李恭才, 顾建章编著. 小儿血管瘤治疗〔M〕. 西安: 陕西科学技术出版社, 1990∶44~45.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EFFECT OF 40% UREA SOLUTION ON THE ISCHEMIA OF LEFT PANCREAS LOBE IN DOG

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