EFFECT OF RECOMBINANT HUMAN GROWTH HORMONE ON IMMUNOLOGIC FUNCTION IN PATIENTS WITH GASTROINTESTINAL MALIGNANT TUMOR_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, The Second Affiliated Hospital of Hunming Medical College, Kunming 650101;

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Keywords：

Recombinant human growth hormone; Gastrointestinal malignant tumor; T lymphocyte subset Soluble interleukin 2 receptor

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To evaluate effect of recombinant human growth hormone (rhGH) on immunologic function in patients with gastrointestinal malignant tumor (GIMT). Before and 3 weeks after surgical treatment and administration of rhGH, the amount of T lymphocyte subset (T-LS) and soluble interleukin 2 receptor (sIL-2R) level were measured in 12 patients with GIMT, which were compared with 20 cases of normal control and 18 cases of GIMT treated by surgery alone. Result: ①In all GIMT patients, the serum CD＋3, CD＋4 level and the ratio of CD＋4/CD＋8 were lower than normal control and the sIL2R level was much higher; ②After operation, the serum CD＋3, CD＋4 level and the ratio of CD＋4/CD＋8 of all patients increased, the serum sIL2R level decreased; ③In patients recieved rhGH, the serum CD＋3, CD＋4 level and the ratio of CD＋4/CD＋8 were much more increased and the serum sIL-2R level much more decreased than those of surgery alone group. Conclusion: rhGH can enhance the immunologic function of patients with GIMT.

Citation： Ran Jianghua,Guo Qun,Zhang Jiahua,et al.. EFFECT OF RECOMBINANT HUMAN GROWTH HORMONE ON IMMUNOLOGIC FUNCTION IN PATIENTS WITH GASTROINTESTINAL MALIGNANT TUMOR. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 298-299. doi: Copy

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2. 李求是. 肿瘤患者手术前后T细胞亚群细胞毒性细胞因子及血浆抑制因子变化. 中国免疫学杂志， 1992； 8(4)∶247.
3. Lotze MT, Finn OJ. Recent advances incellular immunolgy: implications for immunity to cancer. Immunol Today, 1990; 11(6)∶190.
4. Laurencea A, Rubin MD, David L, et al. The soluble interleukin2 receptor biology, function and dinical application. Intern Med, 1990; 113(8)∶619.
5. Semenzato C, Foa R, Agostioni C, et al. High serum levels of soluble interleukin 2 receptor in patients with B chronic lympherytic leukemia. Blood, 1987; 70∶369.
6. Saito H, Fukatsu K, Ming Tsan L, et al. Growth hormone and the immune ressponse to bacterial infection. Horm Res, 1996; 45∶50.
7. Vara Thorbeck R, Guerrero JA, Rosell J, et al. Exogenous growth hormone: effects on the cateabobic response to surgically produced acute stress and on postoperative immune function. World J Surg, 1993; 17(4)∶530.
8. 顾军，黎介寿，李维勤等. 重组生长激素对严重感染后蛋白质代谢影响的研究. 中华外科杂志， 1997； 35(2)∶104.
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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EFFECT OF RECOMBINANT HUMAN GROWTH HORMONE ON IMMUNOLOGIC FUNCTION IN PATIENTS WITH GASTROINTESTINAL MALIGNANT TUMOR

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