ANIMAL EXPERIMENT AND CLINICAL TRIAL OF TREATMENT FOR UNCONTROLLED HEMORRHAGIC SHOCK WITH HYPERTONIC SALINE INFUSION_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Cai Xiujun , Mou Yiping , Peng Shuyou.

Department of Surgery, The Second Affiliated Hospital of Zhejiang Medical University, Hangzhou 310009;

Corresponding author：

Keywords：

Uncontrolled hemorrhagic shock; Hypertonic saline; Blood loss from injured vessels

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In this study, hypertonic saline infusion (experimental group ) and blood transfusion plus normal saline infusion (control group) were used for the treatment of uncontrolled hemorrhagic shock in dogs. The amount of blood loss from injured vessels are compared between two groups. Results: the amount of blood loss from injured vessels in shock stage were 35.2ml in the experimental group and 34.6ml in the control group, which showed no marked difference between two groups(Ｐ＞0.05).The amount of blood loss in resuscitation stage for experimental group was 15.10±1.52ml(early stage) and 14.00±1.37ml(late stage) and for control group was 14.20±1.52ml and 12.90±1.71ml respectively(Ｐ＞0.05).The amount of blood loss in resuscitation stage for both groups is much less than that in shock stage (Ｐ lt;0.05).The results showed that infusion of hypertonic saline 30 min after uncontrolled shock is a safe and effective treatment which dose not cause further bleeding from the injured vessels. Clinical observation also confirmed the result.

Citation： Cai Xiujun,Mou Yiping,Peng Shuyou.. ANIMAL EXPERIMENT AND CLINICAL TRIAL OF TREATMENT FOR UNCONTROLLED HEMORRHAGIC SHOCK WITH HYPERTONIC SALINE INFUSION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(1): 14-15. doi: Copy

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3.	蔡秀军，彭淑牖，江观玉等. 7.5%高渗氯化钠溶液治疗失血性休克20例报告. 实用外科杂志，1992；12(12)∶646.
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1. 彭淑牖.失血性休克时高渗氯化钠的应用.普外临床，1990；5∶350.
2. Traverso LW, Bellamy RF, Hollenbach SJ,et al.Hypertonic NaCl∶effect on hemodynamics and survival after hemorrhage in swine. J Trauma, 1987； 27(1)∶32.
3. 蔡秀军，彭淑牖，江观玉等. 7.5%高渗氯化钠溶液治疗失血性休克20例报告. 实用外科杂志，1992；12(12)∶646.
4. 蔡秀军.高渗氯化钠溶液治疗失血性休克的动物实验研究.浙江医科大学博士论文集，1993.
5. Gross D, Landau EH, Klin B, et al. Quantitative measurement of bleeding following hypertonic saline therapy in uncontrolled hemorrhage shock. J Trauma,1989； 29(1)∶79.
6. Vassar MJ, Perry CA, Holcroft JW, et al.Analysis of potential risks associated with 7.5% sodium chloride resuscitation of traumatic shock. Arch Surg, 1990； 125(10)∶1309.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

ANIMAL EXPERIMENT AND CLINICAL TRIAL OF TREATMENT FOR UNCONTROLLED HEMORRHAGIC SHOCK WITH HYPERTONIC SALINE INFUSION

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