Through dog models of common bile duct obstruction (BDO), the contents of liver superoxide dismutase (SOD) and malondialdehyde(MDA) were measured 2,3,4 and 5 weeks after BDO. Results indicated that the hepatic MDA content was increased 2 weeks after BDO as compared with control group (Ｐ＜0.01), the hepatic SOD content was decreased 3 weeks after BDO (Ｐ＜0.05). When bile duct obstructing, these changed were more serious. The results suggest that liver has little ability to eliminate the superoxide free radicals after BDO, whereas the lipid peroxidation products increase. It may be one of the mechanisms of liver damage after BDO.
Citation：
Li Jing,Chi Yanbang,Fang Xuejun.. CHANGES OF LIVER SUPEROXIDE DISMUTASE AND MALONDIALDEHYDE CONTENTS AFTER BILE DUCT OBSTRUCTION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(3): 148-149. doi:
Copy
Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
| 1. |
Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 1979; 95(2)∶351.
|
| 2. |
迟彦邦，黄志强，张建超等. 实验性胆道阻塞性黄胆对肝、肾、肺的损害. 重庆医药， 1983； 11(6)∶53.
|
| 3. |
李友元，何福清.自由基反应与肝损伤. 国外医学生理病理科学与临床分册，1991； 11(3)∶136.
|
| 4. |
Tsai LY, Lee KT, Tsai SM, et al. Changes of lipid peroxide levels in blood and liver tissue of patients with obstructive jaundice. Chinica Chimica Acta, 1993; 215(1)∶41.
|
| 5. |
程迅生，迟彦邦，祁佐元. 慢性胆道梗阻时肝脏血流量及微血管床的变化. 中华外科杂志， 1992；30 (12)∶ 751.
|
| 6. |
Parks DA. Oxygen radicals∶mediators of gastrointestinal pathophysiology. Gut, 1989; 30(3)∶293.
|
| 7. |
Slater IF. Free radical mechanisms in tissue injury. Biochem J, 1984; 222(1)∶1.
|
- 1. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 1979; 95(2)∶351.
- 2. 迟彦邦，黄志强，张建超等. 实验性胆道阻塞性黄胆对肝、肾、肺的损害. 重庆医药， 1983； 11(6)∶53.
- 3. 李友元，何福清.自由基反应与肝损伤. 国外医学生理病理科学与临床分册，1991； 11(3)∶136.
- 4. Tsai LY, Lee KT, Tsai SM, et al. Changes of lipid peroxide levels in blood and liver tissue of patients with obstructive jaundice. Chinica Chimica Acta, 1993; 215(1)∶41.
- 5. 程迅生，迟彦邦，祁佐元. 慢性胆道梗阻时肝脏血流量及微血管床的变化. 中华外科杂志， 1992；30 (12)∶ 751.
- 6. Parks DA. Oxygen radicals∶mediators of gastrointestinal pathophysiology. Gut, 1989; 30(3)∶293.
- 7. Slater IF. Free radical mechanisms in tissue injury. Biochem J, 1984; 222(1)∶1.
