The aim of this study is to assess ischemia/reperfusion injury in carbon tetrachloride induced cirrhotic liver as compared to normal liver in the rats. Results showed that in cirrhotic liver, instead of diminishing the hepatic vein nitric oxide level increased significantly after ischemia from 8.04 μmol/L to 11.52 μmol/L and remained high till 5 hrs after reperfusion. The hepatic adenosine triphosphate (ATP) contents decreased as that seen in normal rat but did not restore to normal till the end of 5 hrs after reperfusion. Based on these findings, it is postulated that in cirrhotic liver, ischemia/reperfusion injury is aggrvated as evidenced by of nitric oxide, and extended diminishing in ATP.
Citation：
Zhang Zhicheng,Huang Zhiqiang,Meng Xianjun.. THE ROLE OF NITRIC OXIDE, TXA2/PGI2 AND ATP ON HEPATIC ISCHEMIA/REPERFUSION INJURY IN CIRRHOTIC RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(4): 205-207. doi:
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- 1. 韩德五.肝硬化动物模型研究.山西医药杂志， 1979； 4(1)∶1.
- 2. 王成彬，田亚平，沈文梅等.鲁米诺化学发光测定一氧化氮，自由基生命科学进展.北京：原子能出版社，1995∶159.
- 3. 李振甲，王仁芳主编.激素的放射免疫分析.第1版.北京：科学技术文献出版社，1985∶138.
- 4. 严涛，张平，孟宪钧等.荧光素酶系测定组织ATP、ADP、AMP水平的生物发光法.第三军医大学学报，1987； 9(6)∶294.
- 5. Paul CK, Rebecca AS. The emerging multifaceted role of nitric oxide. Ann Surg, 1995; 221∶220.
- 6. Askin DL, Valle MR, Heck DE, et al.Hepatic nitric oxide production following acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression. Hepatology, 1995; 22(3)∶223.
- 7. Beckman JS, Beckman TW, Chen J, et al. Apparent hydroxyl radical production by reroxynitrite:implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA, 1990; 87(8)∶1620.
- 8. Billiar TR. The delicate balance of nitric oxide and superoxide in liver pathology. Gastroenterology, 1995; 108(6)∶603.
- 9. Bush LR, Campbell WB, Buja LM, et al. Effects of the selective thromboxane synthetase inhinitor dazoxiben on variatious in cyclic blood flow in stenosed canine coronary arteriess. Circulation, 1984; 69(9)∶1161.
- 10. Sikujara O, Moden M, Toyoshima K,et al. Cytoprotective effect of prostaglandin I2 on ischemiareperfusion hepatic cell injury. Transpiantantion, 1983; 36(3)∶238.
- 11. Marubayashi S, Takenaka M, Dohi K, et al. Adenine nucleotide metabolism during hepatic ischemia and subequent blood reflow periods and its relation to organ viablity. Transplantaion, 1980; 30(3)∶294.
