SIGNIFICANCE OF THE CHANGES OF DNA CONTENT， ULTRASTRUCTURE AND TUMOR-RELATED ANTIGNES EXPRESSION IN ATYPICAL HYPERPLASIA OF BREAST_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, First Teaching Hospital, Third Military Medical University,Chongqing 400038;

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Keywords：

Atypical hyperplasia of breast; Precancerouse lesion; Deoxyribonucleic acid; UltrastructureTumor-related antignes

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The DNA content, cellular ultrastructure and the expression of blood group Y antigen and immunosuppressive acidic protein-2(IAP-2) were observed in normal breast, cystic hyperplasia of breast and breast cancer. The results showed: the results observed in the cells of cystic hyperplasia with epithelial proliferation grade Ⅰ were similar to those in normal breast cells. The DNA content increased, the hypoplasia and dedifferentiation features in some structures of cellular membrane and nucleus were observed, and the abnormal antigens expressed in part of the atypical hyperplasic cells. The DNA content and ultrastructure in a part of cells with aypical hyperplasia grade Ⅲ were similar to those in the cells of breast cancer grade Ⅰ. The results indicated that in the couse of atypical hyperplasia, the biological abnormalities and its extent of those cells were closely related to the differentiation extent, the developing tendency and the risk of canceration of the cystic hyperplasia of breast.

Citation： Jiang Jun,Zhan Xinen,Chen Yisheng,et al.. SIGNIFICANCE OF THE CHANGES OF DNA CONTENT， ULTRASTRUCTURE AND TUMOR-RELATED ANTIGNES EXPRESSION IN ATYPICAL HYPERPLASIA OF BREAST. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(4): 208-210. doi: Copy

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1. Tavassoli FA, Norris. A comparison of the results of longterm follow up for atypical intraductal hyperplasia and intraductal hyperplasia of the breast. Cancer, 1990; 65(3)∶518.
2. 姜军，詹新恩，柳凤轩.乳腺导管不典型增生与癌变的关系.肿瘤防治研究， 1990； 17(3)∶133.
3. 中华人民共和国卫生部医政司编.中国常见恶性肿瘤诊治规范(第八分册)乳腺癌.北京：北京医科大学中国协和医学院出版社， 1991∶53～57.
4. Vorherr H. Fibrocystic breast disease:pathophysiology, pathomorphology, clinical picture and management. Am J Obstet Gynecol, 1986; 154(1)∶161.
5. Dupont WD, Page DL. Risk factors for breast cancer in woman with proliferative breast disease. New Engl J Med, 1985; 312(3)∶146.
6. Page DL, Dupont WD. Anatomic markers of human premalignancy and risk of breast cancer. Cancer, 1990; 66(6)∶1326.
7. Coon JS, Landay AL, Weinstein RS. Flow cytometric analysis of paraffinembedded tumor，implications for diagnostic pathology. Human Pathol, 1986; 17(5)∶435.
8. Meready RW, Papadimitriou JM. An analysis of DNA cytophotometry on tissue sections in a rat liver model. Anat Quat Cyto, 1983; 5(2)∶117.
9. Lloyd KD. Blood group abtigens as markers for normal differantiation and malignant change in human tissues. Am J Clin Pathol, 1987; 87(1)∶129.
10. Tamura K, Shibata Y, Matsuda Y, et al. Isolation and characterization of an immunosuppressive acidic protein (IAP) from ascitic fluids of cancer patient. Cancer Res, 1981; 41(8)∶3244.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

SIGNIFICANCE OF THE CHANGES OF DNA CONTENT， ULTRASTRUCTURE AND TUMOR-RELATED ANTIGNES EXPRESSION IN ATYPICAL HYPERPLASIA OF BREAST

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