PROLONGATION OF SURVIVAL OF RAT PARATHYROID ALLOGRAFTS BY DEPLETION OF Ⅰa＋ DONOR CELLS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Surgery, Beijing Union Medical College Hospital, Beijing 100730;

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Rat; Parathyroid allograft transplantation; Ⅰa antigen

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In order to reduce the immunogenicity of parathyroid allografts and induce immunotolerance, we depleted Ⅰa＋ donor cells of rat parathyroid allografts by anti-Ⅰa monoclonal antibody plus complement, transplanted the treated glands underneath the capsule of the recipient kindey,and observed the median survival time (MST) of the allografts. Our results showed that the MST of the treated group were 60 days, compared with control group (MST:14 days), Ｐ＜0.01. This results indicate that rat parathyroid allografts survival can be prolonged dramatically by depletion of Ⅰa＋ donor cells.

Citation： Zhang Taiping,Zhu Yu,Wang Shuhui,et al.. PROLONGATION OF SURVIVAL OF RAT PARATHYROID ALLOGRAFTS BY DEPLETION OF Ⅰa＋ DONOR CELLS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(5): 263-264下转269. doi: Copy

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

PROLONGATION OF SURVIVAL OF RAT PARATHYROID ALLOGRAFTS BY DEPLETION OF Ⅰa＋ DONOR CELLS

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