The serum activities of 3 cytokines (TNF,IL-1 and IL-6) were observed in 23 patients admitted within 4 days of onset of acute pancreatitis (AP). The results showed that the serum level of 3 cytokines raised in all of the AP patients, significant difference between TNF and IL-1 was abserved at admission and IL-6 did after one week of admission, suggesting that proper cytokine criteria are useful in predicting severity of the disease but the relationship between cytokines and MOF had not established.
Citation：
Tian Bole,Zhang Zhaoda,Yan Lnan,et al.. CHANGES AND CLINIC SIGNIFICANCE OF CYTOKINES IN PATIENTS WITH ACUTE PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(6): 350-351. doi:
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- 1. Exley AR, Leese T, Holliday MP, et al. Endotoxemia and serum TNF as prognostic markers in severe acute pancreatitis. Gut, 1992; 33(8)∶1126.
- 2. 王建承，赵小团，袁祖荣等.肿瘤坏死因子在急性胰腺炎及并发多器官衰竭中作用的研究.中华医学杂志， 1995；75(3)∶133.
- 3. Kusske AM, Rongione AJ, Reber HA. Cytokines and acute pancreatitis. Gastroenterology, 1996; 110(2)∶639.
- 4. Ranson JHC, Rifkind KM, Roses DF, et al. Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet, 1974; 139(1)∶69５Borzotta AP, Polk Jr HC. Multiplesystem organ failure. Surg Clinic North Am, 1983; 63(2)∶315.
- 5. Mckay C, Brooks B, Gallagher G, et al. Monocyte activation in acute pancreatitis is related to the degree of systemic illness. Digestion, 1992; 52(3)∶104.
- 6. Beaux AC, Goldie AS, Ross JA, et al. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis. Br J Surg, 1996; 83(3)∶349.
