To survey the penetrance of Nimodipine to blood-pancreatic barrier. Pancreatic fluid of 15 cases with pancreatic diseases were respectively sampled from pancreatic drainage tubes at different time after Nimodipine taken orally, and the concentrations of Nimodipine in the fluid were measured with high performance liquid chromatography (HPLC). The average concentration of Nimodipine in pancreatic fluid at 0.5,1,1.5,2,2.5,3,3.5,4 hours after Nimodipine administration were 4.79,7.31,9.21,8.04,6.05,5.11,3.37 and 1.19 ng/ml, respectively. The highest value of Nimodipine level in pancreatic fluid were 9.21 ng/ml at 1.5 to 2 hours following Nimodipine taken orally. These suggested that the Nimodipine can penetrate across the bloodpancreatic barrier and make its pharmacolohical effect in pancreatic tissue.
Citation：
Wang Chen,Zhang Youcheng,Zhang Lingyi,et al.. EFFECTS OF NIMODIPINE ON BLOOD-PANCREATIC BARRIER PENETRANCE IN PATIENTS WITH PANCREATIC DISEASES. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(6): 354-355. doi:
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- 1. Kakarieka A, Braakman R, Schakel EH.European study group on nimodipine in severe head injury:a multicentre trial on the efficacy of nimodipine on outcome after sever head injury. J Neurosurg, 1994; 80∶797.
- 2. Bradley EL Ⅲ. Antibiotics in acute pancreatitis: current status and future directions. Am J Surg, 1989; 158∶472.
- 3. Bassi C, Pederzoli P. Antibiotics in necrotizing pancreatitis. In:Bre-adley EL Ⅲ, eds. Acute Pancreatitis: Diagnosis and Therapy. New York:Raven Press, 1944∶89～92.
- 4. Kerckhoff VD, Drewes W. Transfer of nimodipine and another carcium antagonist across the bloodbrain barrier and their regional distribution in vivo. In: Bergener M, Reisberg B, eds. Diagnosis and Treatment of Senile Dementia. Berlin:SpringerVerlag, 1989∶118～121.
- 5. 周自永，王世祥主编. 新编常用药物手册.第2版.北京：金盾出版社，1992∶120～121.
