The contents of lipid peroxides(LPO)and vitamin E(V.E)and some functional index and histologic changes in the lungs from the the rabbit models of acute cholangitis of severe type(ACST)were measured dynamically.The results revealed that the V.E content decreased strikingly from 6 hours and the LPO level increased progressivelg from 12 hours in the lungs.Simultanuosly,the congestion and neutrophil infiltreation in the lung mesenchyme,and the endothelial cell damage and thrombosis in the lung blood capillaries had been observed.These suggest that acute lung injury induced by ACST is referable to the lipid peroxidation damage to the lung blood capillaries which is due to increased LPO and decreased antioxidants including V.E.
Citation：
Shi Zheng,Yin Fengzhi,Huang Heguang,et al.. EXPERIMENTAL STUDY ON THE ROLE OF LIPID PEROXIDES DURING LUNG INJURY INDUCED BY ACUTE CHOLANGITIS OF SEVERE TYPE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1996, 3(4): 200-202. doi:
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- 1. 刘怀琼.休克讲座及其专题座谈会记要.解放军医学杂志,1987;12:322.
- 2. 石铮.家兔重症急性胆管炎模型的制作.福建医学院学报,1992;26(2):177.
- 3. Ohkawa H.Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction.Anal Biochem,1979;95:351.
- 4. 侯少范,朱振源.生物材料中生育酚的荧光测定法.分析化学,1981;10:535.
- 5. Schoenberg MH.Free oxygen radicals in septic shock.Excepta Medica Section 9,1989;60:361.
- 6. Mcdonald RJ.Neutrophil-derived oxygen metabolities stimulate thromboxane release,pulmonary artery pressure in crease and weight gains in isolated perfuesd rat lung.Am Rev Repir Dis,1987;135:957.
- 7. Fantone JC.Polymorphonuclear leukocyte-mediated cell and tissue injury:oxygen metabolites and their relations to human disease.Hum Pathol,1985;16:973.
- 8. Brigham KL.Role of free radicals in lung injury.Chest,1986;89:859.
