The role of Fas/FasL in the pathogenesis of acute lung injury_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

JIANG Fei ,  FAN Hong

Corresponding author：

FAN Hong, Email: Fanhong28@yahoo.com.cn

Keywords：

Fas/FasL; 急性肺损伤; 致病机制

Video：

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急性肺损伤/急性呼吸窘迫综合征（ALI/ARDS）是指心源性以外的各种肺内外致病因素导致的原发或继发的急性、进行性呼吸衰竭，其病理改变主要表现为肺上皮及内皮细胞的损伤、炎性浸润和透明膜形成，并伴有肺间质纤维化。临床表现为以呼吸窘迫、顽固性低氧血症和非心源性肺水肿为特征的一种急性进行性呼吸困难。采用常规的治疗难以纠正其低氧血症，死亡率高达60%，严重威胁人们的生命健康[1]。自1967年Ashbaugh及其同事首次描述ALI/ARDS以来，医学研究者进行了大量关于ALI/ARDS发病机制及病理生理学的基础及临床研究，但是迄今ALI/ARDS的发病机理仍未完全阐明。近年来越来越多的研究提示凋亡因子（Fas/Fas配体，即Fas/FasL）介导的细胞凋亡在ALI/ARDS的发生发展过程中有着十分重要的作用[2，3]。本文就Fas/FasL的生物学特性及其在ALI/ARDS发病机制中的作用作一综述。

Citation： JIANG Fei,FAN Hong. The role of Fas/FasL in the pathogenesis of acute lung injury. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(2): 145-147. doi: Copy

1.	Ware LB，Matthay MA.The acute respiratory distress syndrome.N Engl J Med，2000，342：1334-1349.
2.	Matute-Bello G，Winn RK，Jonas M，et al.Fas (CD95) induces alveolar epithelial cell apoptosis in vivo：implications for acute pulmonary inflammation.Am J Pathol，2001，158：153-161.
3.	Kitamura Y，Hashimoto S，Mizuta N，et al.Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice.Am J Respir Crit Care Med，2001，163：762-769.
4.	Perl M，Chung CS，Ayala A.Apoptosis.Crit Care Med，2005，33：S526-S529.
5.	French LE，Tschopp J.Protein-based therapeutic approaches targeting death receptors.Cell Death Differ，2003，10：117-123.
6.	Wajant H.Death receptors.Essays Biochem，2003，39：53-71.
7.	Suda T，Takahashi T，Golstein P，et al.Molecular cloning and expression of the Fas ligand，a novel member of the tumor necrosis factor family.Cell，1993，75：1169-1178.
8.	Itoh N，Yonehara S，Ishii A，et al.The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis，Cell，1991，66：233-243.
9.	Peter ME，Krammer PH.The CD95 (APO-1/Fas) DISC and beyond.Cell Death Differ，2003，10：26-35.
10.	Scaffidi C，Fulda S，Srinivasan A，et al.Two CD95 (APO-1/Fas) signaling pathways.EMBO J，1998，17：1675-1687.
11.	Korsmeyer SJ，Wei MC，Saito M，et al.Pro-apoptotic cascade activates BID，which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.Cell Death Differ，2000，7：1166-1173.
12.	Jimenez MF，Watson RW，Parodo J，et al.Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome.Arch Surg，1997，132：1263-1269.
13.	Matute-Bello G，Liles WC，Radella F 2nd，et al.Neutrophil apoptosis in the acute respiratory distress syndrome.Am J Respir Crit Care Med，1997，156：1969-1977.
14.	Kotecha S，Mildner RJ，Prince LR，et al.The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants.Thorax，2003，58：961-967.
15.	Nwakoby JE，Reddy K，Patel P，et al.Fas-mediated apoptosis of neutrophils in sera of patients with infection.Infect Immunol，2001，69：3343-3349.
16.	Dunican AL，Lenemoth SJ，Grutkoski P，et al.TNF alpha-induced suppression of PMN apoptosis is mediated through interleukin-8 production.Shock，2000，14：284-88.
17.	Park WY，Goodman RB，Steinberg KP，et al.Cytokine balance in the lungs of patients with acute respiratory distress syndrome.Am J Respir Crit Care Med，2001，164：1896-1903.
18.	Hu M，Lin X，Du Q，et al.Regulation of polymorphonuclear leukocyte apoptosis：role of lung endothelium-epithelium bilayer transmigration.Am J Physiol Lung Cell Mol Physiol，2005，288：L266-L274.
19.	Nakamura M，Matute-Bello G，Liles WC，et al.Differential response of human lung epithelial cells to Fas-induced apoptosis.Am J Pathol，2004，164：1949-1958.
20.	Albertine KH，Soulier MF，Wang Z，et al.Fas and Fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome.Am J Pathol，2002，161：1783-1796.
21.	Matute-Bello G，Liles WC，Frevert CW，et al.Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits.Am J Physiol Lung Cell Mol Physiol，2001，281：L328-L335.
22.	Neff TA，Guo RF，Neff SB，et al.Relationship of acute lung inflammatory injury to Fas/FasL system.Am J Pathol，2005，166：685-694.
23.	Kinoshita M，Ono S，Mochizuki H.Neutrophils mediate acute lung injury in rabbits：role of neutrophil elastase.Eur Surg Res，2000，32：337-346.
24.	Wortinger MA，Foley JW，Larocque P，et al.Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue.Immunology，2003，110：225-233.
25.	Wang R，Zagariya A，Ang E，et al.Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction.Am J Physiol，1999，277：L1245-L1250.
26.	Hagimoto N，Kuwano K，Inoshima I，et al.TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells.J Immunol，2002，168：6470-6478.
27.	Vazquez de Lara L，Becerril C，Montano M，et al.Surfactant components modulate fibroblast apoptosis and type I collagen and collagenase-1 expression.Am J Physiol Lung Cell Mol Physiol，2000，279：L950-L957.
28.	White MK，Baireddy V，Strayer DS.Natural protection from apoptosis by surfactant protein A in type II pneumocytes.Exp Cell Res，2001，263：183-192.
29.	Scaffidi C，Schmitz I，Krammer PH，et al.The role of c-FLIP in modulation of CD95-induced apoptosis.J Biol Chem，1999，274：1541-1548.
30.	Puneet P，Moochhala S，Bhatia M.Chemokines in acute respiratory distress syndrome Am J Physiol Lung Cell Mol Physiol，2005，288：L3-L15.
31.	Chen JJ，Sun Y，Nabel GJ.Regulation of the proinflammatory effects of Fas ligand (CD95L).Science，1998，282：1714-1717.
32.	Faouzi S，Burckhardt BE，Hanson JC，et al.Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent，caspase-3-dependent pathway.J Biol Chem，2001，276：49077-49082.
33.	Yamaoka-Tojo M，Yamaguchi S，Nitobe J，et al.Dual response to Fas ligation in human endothelial cells：apoptosis and induction of chemokines，interleukin-8 and monocyte chemoattractant protein-1.Coron Artery Dis，2003，14：89-94.

1. Ware LB，Matthay MA.The acute respiratory distress syndrome.N Engl J Med，2000，342：1334-1349.
2. Matute-Bello G，Winn RK，Jonas M，et al.Fas (CD95) induces alveolar epithelial cell apoptosis in vivo：implications for acute pulmonary inflammation.Am J Pathol，2001，158：153-161.
3. Kitamura Y，Hashimoto S，Mizuta N，et al.Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice.Am J Respir Crit Care Med，2001，163：762-769.
4. Perl M，Chung CS，Ayala A.Apoptosis.Crit Care Med，2005，33：S526-S529.
5. French LE，Tschopp J.Protein-based therapeutic approaches targeting death receptors.Cell Death Differ，2003，10：117-123.
6. Wajant H.Death receptors.Essays Biochem，2003，39：53-71.
7. Suda T，Takahashi T，Golstein P，et al.Molecular cloning and expression of the Fas ligand，a novel member of the tumor necrosis factor family.Cell，1993，75：1169-1178.
8. Itoh N，Yonehara S，Ishii A，et al.The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis，Cell，1991，66：233-243.
9. Peter ME，Krammer PH.The CD95 (APO-1/Fas) DISC and beyond.Cell Death Differ，2003，10：26-35.
10. Scaffidi C，Fulda S，Srinivasan A，et al.Two CD95 (APO-1/Fas) signaling pathways.EMBO J，1998，17：1675-1687.
11. Korsmeyer SJ，Wei MC，Saito M，et al.Pro-apoptotic cascade activates BID，which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.Cell Death Differ，2000，7：1166-1173.
12. Jimenez MF，Watson RW，Parodo J，et al.Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome.Arch Surg，1997，132：1263-1269.
13. Matute-Bello G，Liles WC，Radella F 2nd，et al.Neutrophil apoptosis in the acute respiratory distress syndrome.Am J Respir Crit Care Med，1997，156：1969-1977.
14. Kotecha S，Mildner RJ，Prince LR，et al.The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants.Thorax，2003，58：961-967.
15. Nwakoby JE，Reddy K，Patel P，et al.Fas-mediated apoptosis of neutrophils in sera of patients with infection.Infect Immunol，2001，69：3343-3349.
16. Dunican AL，Lenemoth SJ，Grutkoski P，et al.TNF alpha-induced suppression of PMN apoptosis is mediated through interleukin-8 production.Shock，2000，14：284-88.
17. Park WY，Goodman RB，Steinberg KP，et al.Cytokine balance in the lungs of patients with acute respiratory distress syndrome.Am J Respir Crit Care Med，2001，164：1896-1903.
18. Hu M，Lin X，Du Q，et al.Regulation of polymorphonuclear leukocyte apoptosis：role of lung endothelium-epithelium bilayer transmigration.Am J Physiol Lung Cell Mol Physiol，2005，288：L266-L274.
19. Nakamura M，Matute-Bello G，Liles WC，et al.Differential response of human lung epithelial cells to Fas-induced apoptosis.Am J Pathol，2004，164：1949-1958.
20. Albertine KH，Soulier MF，Wang Z，et al.Fas and Fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome.Am J Pathol，2002，161：1783-1796.
21. Matute-Bello G，Liles WC，Frevert CW，et al.Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits.Am J Physiol Lung Cell Mol Physiol，2001，281：L328-L335.
22. Neff TA，Guo RF，Neff SB，et al.Relationship of acute lung inflammatory injury to Fas/FasL system.Am J Pathol，2005，166：685-694.
23. Kinoshita M，Ono S，Mochizuki H.Neutrophils mediate acute lung injury in rabbits：role of neutrophil elastase.Eur Surg Res，2000，32：337-346.
24. Wortinger MA，Foley JW，Larocque P，et al.Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue.Immunology，2003，110：225-233.
25. Wang R，Zagariya A，Ang E，et al.Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction.Am J Physiol，1999，277：L1245-L1250.
26. Hagimoto N，Kuwano K，Inoshima I，et al.TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells.J Immunol，2002，168：6470-6478.
27. Vazquez de Lara L，Becerril C，Montano M，et al.Surfactant components modulate fibroblast apoptosis and type I collagen and collagenase-1 expression.Am J Physiol Lung Cell Mol Physiol，2000，279：L950-L957.
28. White MK，Baireddy V，Strayer DS.Natural protection from apoptosis by surfactant protein A in type II pneumocytes.Exp Cell Res，2001，263：183-192.
29. Scaffidi C，Schmitz I，Krammer PH，et al.The role of c-FLIP in modulation of CD95-induced apoptosis.J Biol Chem，1999，274：1541-1548.
30. Puneet P，Moochhala S，Bhatia M.Chemokines in acute respiratory distress syndrome Am J Physiol Lung Cell Mol Physiol，2005，288：L3-L15.
31. Chen JJ，Sun Y，Nabel GJ.Regulation of the proinflammatory effects of Fas ligand (CD95L).Science，1998，282：1714-1717.
32. Faouzi S，Burckhardt BE，Hanson JC，et al.Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent，caspase-3-dependent pathway.J Biol Chem，2001，276：49077-49082.
33. Yamaoka-Tojo M，Yamaguchi S，Nitobe J，et al.Dual response to Fas ligation in human endothelial cells：apoptosis and induction of chemokines，interleukin-8 and monocyte chemoattractant protein-1.Coron Artery Dis，2003，14：89-94.

Chinese Journal of Respiratory and Critical Care Medicine

The role of Fas/FasL in the pathogenesis of acute lung injury

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