• Department of Respiratory Medicine,Fujian Provincal Hospital,Fujian Provincial Medical College ,Fujian Medical University.Fuzhou,Fujian, 350001,China Corresponding author : CHEN Yu-sheng , E-mail : slyyywb@yahoo.com.cn;
CHEN Yusheng, Email: slyyywb@yahoo.com.cn
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Objective  To detect the levels and study the significance of serum soluble intercellular adhension molecule-1(sVCAM-1),soluble vascular cell adhension molecule-1 (sVCAM-1) in patients with community-acquired pneumonia(CAP).Methods  sICAM-1 and sVCAM-1 were detected by enzymelinked immunosorbent assy(ELISA)in 25 patients with CAP before and after treatment as well as in 10 healthy controls.Results  Before treatment, the levels of serum sICAM-1 and sVCAM-1 in the patients with CAP[(2.658 4±0.259 7)ng/mL,(2.680 9±0.255 4)ng/mL)] were significantly higher than those in controls[(2.472 8±0.077 6)ng/mL,(2.426 3±0.307 2)ng/mL](P lt;0.01,P lt;0.05). After treatment, the levels of serum sICAM-1, sVCAM-1 significantly decreased [(2.518 3±0.205 2)ng/mL,(2.523 0±0.279 4)ng/mL](P lt;0.01,P lt;0.01) and were not different from those in controls(P gt;0.05).The levels of sICAM-1 were positively associated with neutrophil counts(r=0.602,P lt;0.001)rather than the levels of sVCAM-1(r=0.036,P gt;0.05).Conclusion  The changes of sICAM-1 and sVCAM-1 before and after treatment are predictive to the prognosis in patients with CAP.

Citation: CHEN Yusheng,XIE Baosong,LIN Ming,XU Nengluan,LIN Zhangshu,LI Ruihui,LI Hongru,LIN Lifang. Significance of serum soluble intercellular adhension molecule-1 and soluble vascular cell adhension molecule-1 in patients with community-acquired pneumonia. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(1): 26-29. doi: Copy

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