• Department of Respiration of Beijing University Shenzhen Hospital.Shenzhen,Guandong,518034,ChinaCorresponding author:PI Jia-li,E-mail:pijiali3@sina.com;
PI Jiali , Email: pijiali3@sina.com
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Objective   To investigate the expressions of insulin like growth factor binding protein -3 ( IGFBP-3 ) in serum and bronchoalveolar lavagae fluids ( BALF ) of patients with non-small cell lung cancer , and explore the clinical significance in dignosis and prognosis of lung cancer.Methods   The bronchoalveolar lavagae fluids ( BALF ) were collected by bronchoscopy in 80 cases with non-small cell lung cancer and 14 healthy subjects.The expression of IGFBP-3 in serum and BALF were detected by immunoradioassay.Results  The expression of IGFBP-3 in serum and BALF of lung cancer group were significantly lower than that of health group(P lt;0.05).IGFBP-3 levels were significantly lower in those patients with lymphoid node metastasis or metastasis or TNMⅢ-TNMⅣ than those without metastasis or TNMⅠ-TNMⅡ(P lt;0.05).In lung cancer group,the levels of the IGFBP-3 in serum and BALF had a significantly positive correlation(r=0.415,r=0.355,P lt;0.01).Conclusion  The IGFBP-3 may play an important role in the development of non-small cell lung cancer and is valuable in dignosis and prognosis of lung cancer.

Citation: PI Jiali ,XU Ping,SONG Weidong,LIU Yuanyuan.. Clinical significance of insulin like growth factor binding protein 3 in patients with lung cancer. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(1): 57-60. doi: Copy

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