The inhibitory effects of ginkgo biloba extract on airway and vascular remodeling in rat model of chronic obstructive pulmonary disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 TAN Yuping ¹ , WANG Zhaohui ¹ , MENG Dingshui ¹ , YAO Ping ² , ZHONG Xiaoning ³ , HUANG Xiujie ¹ , HUANG Jinlong ¹

Geriatric Department of Ruikang Hospital Affiliated to Guangxi Traditional Chinese Medical University.Nanning，Jiangsu，530011，China Corresponding author：TAN Yu-ping，E-mail：tanlaoshi1226@126.com;

Corresponding author：

TAN Yuping , Email: tanlaoshi1226@126.com

Keywords：

Chronic obstructive pulmonary disease; Ginkgo biloba extract; Airway remodeling; Pulmonary vascular remodeling

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Objective To study the intervention effect of ginkgo biloba extract（GBE） on airway and vascular remodeling in rat model of chronic obstructive pulmonary disease(COPD).Methods Forty wistar rats were randomly divided into group A，B，C and D.The rat model of COPD were established by intratracheally injection of lipopolysaccharide and exposure to cigarette smoke in groups B，C and D.Groups C and D were given intraperitoneally injection with 40 mg/kg GBE respectively from day1 to day14 and day29 to day42.Forty-three days later，the rats were sacrificed for lung pathological examination.Results Group B，C and D all showed pathological changes characteristic of COPD to different extent.The average area and standard number of alveoli showed significant difference between each groups（all P lt;0.01）.The structure of bronchiole walls in group C and D show mild changes.The ratio of bronchial smooth muscle thickness to bronchial wall thickness and bronchial wall area to bronchial area of group C and D showed significant difference when compared with group A and B（all P lt;0.01）.The vascular smooth muscle cell of group C and D had mild hyperplasia and the vascular wall had slightly thickened.The ratio of vascular smooth muscle thickness to vascular wall thickness and vascular wall area to vascular area in group C and D showed significant difference when compared with group A and B（all P lt;0.01）.Conclusion GBE has inhibitory effects on airway and vascular remodeling in rats model of COPD.

Citation： TAN Yuping ,WANG Zhaohui,MENG Dingshui,YAO Ping,ZHONG Xiaoning,HUANG Xiujie,HUANG Jinlong. The inhibitory effects of ginkgo biloba extract on airway and vascular remodeling in rat model of chronic obstructive pulmonary disease. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(4): 274-276. doi: Copy

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3.	柴秀娟，骆仙芳，黄卫华，等.SO2、木瓜蛋白酶致大鼠肺气肿模型的建立及应用.中国中医基础医学杂志，2003，9：23-27.
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5.	Kerstjens HA，Timens W.Phosphodiesterase 4 inhibitors：antiinflammatory therapy for chronic obstructive pulmonary disease at last?Am J Respir Crit Care Med，2003，168：914-915.
6.	施焕中，林江涛，主编.肺脏免疫学及免疫相关性疾病.北京：人民卫生出版社，2006，581-585.
7.	Santos S，Peinado VI，Ramírez J，et al.Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD.Eur Respir J，2002，19：632-638.
8.	Fabbri LM，Luppi F，Beghé B，et al.Update in chronic obstructive pulmonary disease 2005.Am J Respir Crit Care Med，2006，173：1056-1065.
9.	钟小宁，郭韶梅.慢性支气管炎与肺气肿大鼠肺血管炎症的实验研究.中华结核和呼吸杂志，2006，29：435-439.
10.	Oyama Y，Chikahisa L，Ueha T，et al.Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide.Brain Res，1996，712：349-352.
11.	张宏，孟亚娟，斯琴，等.银杏叶提取物对脂多糖诱导大鼠急性肺损伤的保护作用.基础医学与临床，2002，22：155-158.

1. Faller DV.Endothelial cell responses to hypoxic stress.Clin Exp Pharmacol Physiol，1999，26：74-84.
2. 朱慧志，韩明向，丁小娟，等.多因素慢性阻塞性肺疾病大鼠模型的建立.中国临床保健杂志，2005，8：145-146.
3. 柴秀娟，骆仙芳，黄卫华，等.SO2、木瓜蛋白酶致大鼠肺气肿模型的建立及应用.中国中医基础医学杂志，2003，9：23-27.
4. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.COPD诊治指南（2007年修订版）.继续医学教育，2007，21：31-42.
5. Kerstjens HA，Timens W.Phosphodiesterase 4 inhibitors：antiinflammatory therapy for chronic obstructive pulmonary disease at last?Am J Respir Crit Care Med，2003，168：914-915.
6. 施焕中，林江涛，主编.肺脏免疫学及免疫相关性疾病.北京：人民卫生出版社，2006，581-585.
7. Santos S，Peinado VI，Ramírez J，et al.Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD.Eur Respir J，2002，19：632-638.
8. Fabbri LM，Luppi F，Beghé B，et al.Update in chronic obstructive pulmonary disease 2005.Am J Respir Crit Care Med，2006，173：1056-1065.
9. 钟小宁，郭韶梅.慢性支气管炎与肺气肿大鼠肺血管炎症的实验研究.中华结核和呼吸杂志，2006，29：435-439.
10. Oyama Y，Chikahisa L，Ueha T，et al.Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide.Brain Res，1996，712：349-352.
11. 张宏，孟亚娟，斯琴，等.银杏叶提取物对脂多糖诱导大鼠急性肺损伤的保护作用.基础医学与临床，2002，22：155-158.

Chinese Journal of Respiratory and Critical Care Medicine

The inhibitory effects of ginkgo biloba extract on airway and vascular remodeling in rat model of chronic obstructive pulmonary disease

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