Objective To investigate the effect of intra-abdominal hypertension(IAH) on respiratory function in pigs.Methods Twelve pigs were randomly divided into two groups (n=6 in each group),ie.IAH20 group(intra-abdominal pressure=20 mm Hg) and IAH30 group(intra-abdominal pressure=30 mm Hg).Pig model of IAH was established by intraperitoneally injection of carbon dioxide.The changes in respiratory function parameters including pulmonary dynamic compliance（Cdyn），peak inspiratory pressure(PIP) ,SpO2 and PaCO2 were recorded at different time points.Results Cdyn was significantly decreased at different time points compared with baseline in group IAH30 and group IAH20.PIP significantly increased at different time points compared with baseline in both IAH groups，but group IAH30 was more severe than group IAH20. No significant changes of SpO2 and PaCO2 were found in two IAH groups.Conclusion IAH can impair respiratory function by decreasing lung compliance and increasing inspiratory pressure.
Citation：
HU Jianhua ,WANG Daqing,TU Faping,CHEN Bin,GE Ying,LIU Shaoxing,GONG Zonglian,WAN Yong. Influence of intra-abdominal hypertension on respiratory function in pigs. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(5): 383-384. doi:
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Copyright © the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved
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- 2. Saggi BH，Sugerman HJ，Ivatury RR，et al.Abdominal compartment syndrome.J Trauma，1998，45：597-609.
- 3. Malbrain ML，Chiumello D，Pelosi P，et al.Prevalence of intra-abdominal hypertension in critically ill patients：a multicentre epidemiological study.Intensive Care Med，2004，30：822-829.
- 4. 万勇，葛颖，王大庆，等.膀胱压、胃内压与腹内压的相关性研究.中国普外基础与临床杂志，2003，10：383-384.
- 5. Sugrue M.Abdominal compartment syndrome.Curr Opin Crit Care，2005，11：333-338.
- 6. 程君涛，肖光夏，张诚华，等.改良腹内高压动物模型制作及动脉血气分析.第三军医大学学报，2005，27：2189-2190.
- 7. Pelosi P，D’Onofrio D，Chiumello D，et al.Pulmonary and extrapulmonary acute respiratory distress syndrome are different.Eur Respir J，2003，22(Suppl)：48-56.
- 8. Malbrain MLNG，Deeren DH，de Potter T，et al.Partioning of respiratory mechanics in intra-abdominal hypertension.ANZ J Surg，2005，75：A9.
