Effect of Paroxetine on Sleep Apneas in Sprague-Dawley Rats_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WANG Yao ¹ ,  WANG Guangfa ² , ZHANG Cheng. ²

Department of Critical Care Medicine, Peking University School of Oncology, Beijing Cancer Hospital.Beijing, 100142, China;

Corresponding author：

WANG Guangfa, Email: wangguangfa@hotmail.com

Keywords：

Sleep apnea syndrome; Paroxetine; Selective serotonin reuptake inhibitor

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Objective To evaluate the effects of selective serotonin reuptake inhibitors ( SSRIs) on sleep apneas in Sprague-Dawley ( SD) rats. Methods Thirty adultmale SD rats were randomly divided into two groups ( 15 rats in each group) . The treatment group and the control group were injected intraperitoneally with paroxetine ( 10 mg· kg- 1 · d - 1 ) and sterile distilled water ( 2 mL· kg- 1 · d - 1) for 7 days respectively. Parameters about sleep apnea and sleep structure were measured before and after the treatment. Results In the treatment group, there was a significant reduction of apnea index ( AI) from ( 12. 4 ±3. 7)times /hour to ( 7. 4 ±2. 2) times/ hour ( P = 0. 000) . Both post sigh apnea index ( PSAI) and spontaneous apnea index ( SPAI) were decreased significantly ( P = 0. 000 and 0. 021 respectively) in non-rapid eye movement ( NREM) sleep, but not in REM sleep. REM sleep was reduced from 8. 6% to 8. 0% ( P =0. 013) and its latency was increased from ( 54. 1 ±48. 4) min to ( 110. 9 ±43. 4) min ( P = 0. 001) in the treatment group, as well as the sleep-onset latency [ from ( 20. 7 ±9. 1) min to ( 30. 0 ±15. 7) min, P =0. 038] . Conclusion Paroxetine can reduce sleep apneas in SD rats during NREMsleep. Its effects on sleep structure include reducing REM time, increasing REM latency and sleep-onset latency.

Citation： WANG Yao,WANG Guangfa,ZHANG Cheng.. Effect of Paroxetine on Sleep Apneas in Sprague-Dawley Rats. Chinese Journal of Respiratory and Critical Care Medicine, 2009, 09(4): 384-387. doi: Copy

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1. 王菁, 王广发, 凌亦凌. 自由活动大鼠睡眠状态和呼吸节律的同步监测方法. 中国应用生理学杂志, 2004, 20: 310-312.
2. 王菁, 王广发, 凌亦凌. 成年Sprague-Dawley 大鼠的睡眠结构和呼吸暂停分析. 中国病理生理杂志, 2005, 21: 621-624.
3. Sood S, Morrison JL, Liu H, et al. Role of endogenous serotonin in modulating genioglossus muscle activity in awake and sleeping rats.Am J Respir Crit Care Med, 2005, 172: 1338-1347.
4. Kraiczi H, Hedner J, Dahl　f P, et al. Effect of serotonin uptake inhibition on breathing during sleep and daytime symptoms in obstructive sleep apnea. Sleep, 1999, 22: 61-67.
5. 杜秀芳, 廖理粤, 陈荣昌, 等. 睡眠呼吸暂停/低通气综合征体重指数与睡眠结构及呼吸紊乱关系探讨. 中国呼吸与危重监护杂志, 2005, 4: 362-364.
6. Veasey SC. Serotonin agonists and antagonists in obstructive sleep apnea: therapeutic potential. Am J Respir Med, 2003 , 2: 21 -29 .
7. -HT1A 和5-HT2 受体功能与觉醒、睡眠成分关系的研究. 中国药理学通报, 2000, 16: 208-211.
8. 张成, 王菁, 王广发, 等. 钾离子通道TASK-1、TASK-3 在大鼠脑干的表达与睡眠呼吸暂停的关系. 中华医学杂志, 2007, 87:2929-2931.
9. Schl　sser R, R　schke J, Rossbach W, et al. Conventional and spectral power analysis of all-night sleep EEG after subchronic treatment with paroxetine in healthy male volunteers. Eur Neuropsychopharmacol, 1998, 8: 273-278.
10. 靳照宇, 库宝善, 姚海燕, 等.
11. 韩济生, 主编. 神经科学原理. 第2 版. 北京: 北京医科大学出版社, 1999, 504-524.

Chinese Journal of Respiratory and Critical Care Medicine

Effect of Paroxetine on Sleep Apneas in Sprague-Dawley Rats

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