Objective To explore the risk factors of invasive fungal infection ( IFI) in respiratory ward. Methods A multi-center, retrospective, case-control study was carried out. Patients from five general hospitals in Chongqing city, diagnosed as fungal infection, or whose respiratory specimens were fungal positive, were retrospectively screened for IFI. Patients with respiratory infection and colonization of nonfungal cases in the same period of hospitalization were enrolled as control. Results Thirty-four patients diagnosed with IFI and 50 patients diagnosed with bacterial infection were analyzed for the risk factors of IFI. The demographic characteristics of patients including age and gender were not different( P gt; 0. 05) , but hospitalization days, carbapenem antibiotic use, chemotherapy, deep venous catheterization, total parenteral
nutrition( TPN) , neutropenia, and renal disfunction were different significantly between the IFI group and the control group. Multiple logistic regression analysis showed that carbapenem antibiotic use ( OR = 6. 753) ,central venous catheterization ( OR = 5. 021) and TPN ( OR = 3. 199) were main risk factors of invasive fungal infection. Conclusion The carbapenem antibiotic use, central venous catheterization and TPN are risk factors for IFI in respiratory ward.
Citation：
WU Xueling,LI Xuejun,CHEN Hong,WANG Daoxin,CAO Guanming,WANG Changzheng. Risk Factors of Invasive Fungal Infection in Respiratory Ward: A Retrospective Case Control Study. Chinese Journal of Respiratory and Critical Care Medicine, 2009, 09(6): 544-546. doi:
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Copyright © the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved
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陈瑞英, 靳建军, 欧阳松云, 等. 非中性粒细胞缺乏患者发生侵袭性曲霉病的危险因素、临床特征及预后分析. 中国呼吸与危重监护杂志, 2008, 7: 169-173.
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Leon C, Ruiz-Santana S, Saaverdra P, et al. A bedside scoring system ( “Candida score”) for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med, 2006, 34, 730-737.
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- 1. Cuenca EM, Bernal ML, Buitrago MJ, et al. Update on the epidemiology and diagnosis of invasive fungal infection. Int J Antimicrob Agents, 2008, 32: S143-S147.
- 2. Castón-Osorio JJ, Rivero A, Torre-Cisneros J. Epidemiology of invasive fungal infection. Int J Antimicrob Agents, 2008 , 32: S103 -S109.
- 3. vallés J, Mesalles E, Mariscal D, et al. A 7-year study of severe hospital-acquired pneumonia requiring ICU admission. Inten Care Med, 2003, 29: 1981-1988.
- 4. 年间医院内侵袭性真菌感染的病原菌分布及临床分析. 中华医院感染学杂志, 2008, 18: 1030-1033.
- 5. 冯文莉, 杨静, 奚志琴, 等.
- 6. Ostrosky-Zeichner L, Pappas PG. Invasive candidiasis in the intensive Care Unit. Crit Care Med, 2006 , 34 : 857-863.
- 7. 邵剑峰. 医院真菌感染临床调查研究. 中华医院感染学杂志,2008, 18: 1192-1194.
- 8. 中国侵袭性肺部真菌感染工作组. 侵袭性肺部真菌感染的诊断标准与治疗原则( 草案) . 中国实用内科杂志, 2006, 26: 1748-1751.
- 9. Charles PE, Daller F, Aube H, et al. Candida spp. colonization significance in critically ill medical patients: a prospective study.Intensive Care Med, 2005, 31: 393-400.
- 10. 陈瑞英, 靳建军, 欧阳松云, 等. 非中性粒细胞缺乏患者发生侵袭性曲霉病的危险因素、临床特征及预后分析. 中国呼吸与危重监护杂志, 2008, 7: 169-173.
- 11. Leon C, Ruiz-Santana S, Saaverdra P, et al. A bedside scoring system ( “Candida score”) for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med, 2006, 34, 730-737.
