Objective To observe the serumlevel of neuron-specific enolase( NSE) in patients with pulmonary encephalopathy and its changes after treatment with mechanical ventilation. Methods Twentyone patients with pulmonary encephalopathy were enrolled. Glasgow coma scale( GCS) , serumNSE level, and arterial blood gas were evaluated at three time-points: before mechanical ventilation, after 12 hours mechanical ventilation, and the moment of consciousness. Results 18 patients recovered consciousness, and 3 patients remained in persistent coma and died. GCS and arterial blood gas improved obviously after 12 hours mechanical ventilation. Meanwhile, the serumNSE concentration decreased significantly after 12 hours mechanical ventilation [ ( 24. 54 ±6. 65) μg/L] and at the moment of consciousness [ ( 14. 19 ±2. 91) μg/L] compared with before mechanical ventilation( P lt; 0. 05, P lt; 0. 01) . Conclusion Dynamic measurment of serumNSE may be a useful biomarker for assessing the severity of cerebral injury and predicting prognosis.
Citation：
CUI Ke,XU Yinghe,LIN Ronghai,SHAN Renfei,CHEN Zhongteng.. Serum Level of Neuron-Specific Enolase and Its Changes after Treatment with Mechanical Ventilation in Patients with Pulmonary Encephalopathy. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(3): 278-280. doi:
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陈绍平, 陈小兵, 刘立兴, 等. 肺性脑病患者血清神经元特异性烯醇化酶测定及临床意义. 中国呼吸与危重监护杂志, 2003,2:230-232.
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史玉泉, 周孝达, 主编. 实用神经病学. 第3 版. 上海: 上海科学技术出版社, 2004 , 1375 -1376.
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- 1. 刘菊英, 杨红忠, 颜关明. 肺性脑病患者血清神经元特异性烯醇化酶活性的研究. 湖南医科大学学报, 2000 , 25: 281 -282.
- 2. Lückl J, Farkas O, Pál J, et al. Protein biomarkers in experimental models and in clinical care of traumatic brain injury. Ideggyogy Sz,2007, 60: 284 -294.
- 3. Odagiri E. Neuron specific enolase. Nippon Rinsho, 2005, 63 Suppl 8 : 717-719.
- 4. Anand N, Stead LG. Neuron-specific enolase as a marker for acute ischemic stroke: a systematic review. Cerebrovasc Dis,2005,20: 213-219.
- 5. Nguyen DN, Spapen H, Su F, et al. Elevated serum levels of S-100 beta protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock. Crit Care Med,2006, 34: 1967-1974.
- 6. 陈绍平, 陈小兵, 刘立兴, 等. 肺性脑病患者血清神经元特异性烯醇化酶测定及临床意义. 中国呼吸与危重监护杂志, 2003,2:230-232.
- 7. 史玉泉, 周孝达, 主编. 实用神经病学. 第3 版. 上海: 上海科学技术出版社, 2004 , 1375 -1376.
