Changes of Airway Resistances before and after Bronchial Dilation Test in COPD and Asthma_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

XIONG Shuguang , WANG Hui , WU Liang , ZHOU Ling , MEN Yaling.

Department of Respiratory Medicine,The 416 Hospital of China National Nuclear Industry. Chengdu, Sichuan,610051, ChinaCorresponding Author: XIONG Shu-guang, E-mail: bearguang66@ yahoo. cn;

Corresponding author：

Keywords：

Chronic obstructive pulmonary disease; Asthma; Airway resistance; Impulse oscilometry; Lung fuction; Bronchial dilation test

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the profile and diagnosis value of airway resistances before and after bronchial dilation test ( BDT) in patients with COPD and asthma. Methods Airway resistances before and after BDT were measured in COPD patients and asthma patients with different severity by impulse oscillometry ( IOS) , and the characteristic changes of the two different diseases were analyzed compared with healthy subjects. Results Airway resistance indexes except X5 were higher in the COPD and the asthma patients than those in the healthy subjects before BDT ( P lt; 0. 05) . There were significant differences in airway resistance indexes except X5 and Rc between the mild asthma patients and the moderate to severe asthma patients. Significant difference in Z5, Fres, and Rp were observed in the mild COPD patients
compared with the moderate to severe COPD patients. There were statistical differences in airway resistance indexes except X5 between the two groups before and after BDT both in the COPD and the asthma patients ( P lt;0. 05) . The rates of change in Z5, Fres, R5, and Rp were higher than those of FEV1% pred, especially higher in the asthma patients than in the COPD patients ( P lt; 0. 05) . Significant negative correlations between FEV1% pred and Z5, Fres, R5, Rp were revealed in the COPD and the asthma patients ( P lt;0. 01) .The correlation between Fres and FEV1% pred was most significant in the COPD and the asthma patients ( r = - 0. 561, - 0. 761) . Conclusion Airway resistances measured by IOS is sensitive indicators in detecting the airflow obstruction in COPD and asthma, and is useful in early and differential diagnosis of COPD and asthma.

Citation： XIONG Shuguang,WANG Hui,WU Liang,ZHOU Ling,MEN Yaling.. Changes of Airway Resistances before and after Bronchial Dilation Test in COPD and Asthma. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(4): 369-373. doi: Copy

Brand PL, Quanjer PH, Postma DS, et al. Interpretation of bronchodilator response in patients with obstructive airways disease.The Dutch Chronic Non-Specific Lung Disease ( CNSLD) Study Group. Thorax, 1992, 47 : 429-436. 2 Dompeling E, van Schayck CP, Molema J, et al. A comparison of six different ways of expressing the bronchodilating response in asthma and COPD; reproducibility and dependense of prebronchodilator FEV1 . Eur Respir J, 1992, 5: 975-981. 3 Anthonisen NR, Lindgren PG, Tashkin DP, et al. Bronchodilator responre in the lung health study over 11 yrs. Eur Respir J, 2005 ,26: 45 -51 . 4 中华医学会呼吸病学分会. 支气管哮喘防治指南( 支气管哮喘的定义、诊断、治疗、疗效判断及教育管理方案) . 中华结核和呼吸杂志, 1997, 20 : 266. 5 邓家珍, 钟小宁, 梁国容. IOS 新技术在COPD 患者气道阻力测定中的应用. 广西医科大学学报, 2003, 20: 527 -528. 6 叶青, 黄克武, 章利云, 等. 临床控制的支气管哮喘患者外周气道状态的研究. 中华结核和呼吸杂志, 2009, 32: 206-207. 7 王廷杰, 王平飞, 王家驷, 等. 最大通气量测定前后气道阻力变化对咳嗽变异型哮喘的诊断价值探讨. 中国呼吸与危重监护杂志, 2007, 6: 249 -252. 8 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南( 2007 年修订版) . 中华结核和呼吸杂志,2007, 30: 8-17. 9 Dubious AB, Brody AW, Lewis DH, et al. Oscillation mechanics of lung and chest in man. J Appl Physiol, 1956, 8: 587 -694. 10 郑劲平, 主编. 肺功能学-基础与临床. 广州: 广东科学技术出版社, 2007, 173-184.

1. Brand PL, Quanjer PH, Postma DS, et al. Interpretation of bronchodilator response in patients with obstructive airways disease.The Dutch Chronic Non-Specific Lung Disease ( CNSLD) Study Group. Thorax, 1992, 47 : 429-436. 2 Dompeling E, van Schayck CP, Molema J, et al. A comparison of six different ways of expressing the bronchodilating response in asthma and COPD; reproducibility and dependense of prebronchodilator FEV1 . Eur Respir J, 1992, 5: 975-981. 3 Anthonisen NR, Lindgren PG, Tashkin DP, et al. Bronchodilator responre in the lung health study over 11 yrs. Eur Respir J, 2005 ,26: 45 -51 . 4 中华医学会呼吸病学分会. 支气管哮喘防治指南( 支气管哮喘的定义、诊断、治疗、疗效判断及教育管理方案) . 中华结核和呼吸杂志, 1997, 20 : 266. 5 邓家珍, 钟小宁, 梁国容. IOS 新技术在COPD 患者气道阻力测定中的应用. 广西医科大学学报, 2003, 20: 527 -528. 6 叶青, 黄克武, 章利云, 等. 临床控制的支气管哮喘患者外周气道状态的研究. 中华结核和呼吸杂志, 2009, 32: 206-207. 7 王廷杰, 王平飞, 王家驷, 等. 最大通气量测定前后气道阻力变化对咳嗽变异型哮喘的诊断价值探讨. 中国呼吸与危重监护杂志, 2007, 6: 249 -252. 8 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南( 2007 年修订版) . 中华结核和呼吸杂志,2007, 30: 8-17. 9 Dubious AB, Brody AW, Lewis DH, et al. Oscillation mechanics of lung and chest in man. J Appl Physiol, 1956, 8: 587 -694. 10 郑劲平, 主编. 肺功能学-基础与临床. 广州: 广东科学技术出版社, 2007, 173-184.

Chinese Journal of Respiratory and Critical Care Medicine

Changes of Airway Resistances before and after Bronchial Dilation Test in COPD and Asthma

Abstract Full text Figures/Tables Video References Cited by

Format

Content