LIU Shaohua , YANG Xiaodong , WANG Yanting
  • Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University. Chengdu, Sichuan, 610041, China Corresponding Author: YANG Xiao-dong, E-mail: yang-xiaodong@ 163. com;
Kartagener syndrome; Primary ciliary dyskinesia; Chronic sinusitis; Bronchiectasis; Situs inversus
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Objective  To improve the knowledge of kartagener syndrome and the understanding of primary ciliary dyskinesia ( PCD) .
Methods  Three cases of Kartagener syndrome were reported and analyzed on clinical manifestations, symptoms, imaging appearances of chest, and family history. Meanwhile the related literatures were reviewed.
Results  The three patients deserved special recognition because of recurrent upper and lower respiratory tract infection. Of them, the third case showed mainly the symptoms of nasosinusitis at an early age, and the distinct pulmonary symptoms appeared in his adulthood. Further examination showed that the triad of chronic sinusitis, bronchiectasis, and situs inversus is present in all cases. The parents of the two cases were consanguineous marriaged. Examination of the bronchial mucosal biopsy specimen of the first case under transmission electron microscopy showed cilia with the absence of inner dynein arms. The three cases got improvement after treatment of anti-infection and expectorant.
Conclusion  For patients with recurring infection in the upper and lower respiratory tract from infancy, the possibility of PCD should be considered no matter whether a situs inversus exists.

Citation： LIU Shaohua,YANG Xiaodong,WANG Yanting. Kartagener Syndrome: Three Cases Report and Literature Review. Chinese Journal of Respiratory and Critical Care Medicine, 2012, 11(3): 267-269. doi: Copy

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