• Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University. Chengdu, Sichuan, 610041, China;
Asthma; Acute exacerbation; Montelukast; Systematic review; GRADE system; Meta analysis
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Objective  To systematically evaluate the efficacy and safety of montelukast in the treatment of acute asthma in adults.
Methods  Randomized controlled trials ( RCTs) of montelukast in the treatment of acute asthma compared with placebo were searched in Pubmed, Embase, OVID, and Cochrane Library. The quality of included RCTs was evaluated and the data were extracted. Meta-analyses were performed with RevMan 5. 1 software, and the GRADE system was applied to rate the level of evidence and strength of recommendation.
Results  Five RCTs ( n = 947) were included. Meta-analyses showed that montelukast could statistically improve peak expiratory flow ( PEF) ( MD = 10. 65 [ 2. 81, 18. 49] , P = 0. 008) , reduce the number of patients with oral corticosteroids ( RR=0. 75[ 0. 62, 0. 92] , NNT= 7[ 4, 46] , P =0. 005) , but there were no statistical differences in decreasing the number of patients with hospitalizations ( RR= 0. 78[ 0. 57, 1. 06] , NNT = 19[ 9, + ∞] , P = 0. 110) and treatment failure ( RR = 0. 85[ 0. 67, 1. 09] , NNT=17[ 9, +∞] , P =0. 314) compared with the placebo. Based on GRADE, the level of evidence was low or moderate, and the strength of recommendation was weak.
Conclusion  Our study suggests montelukast can improve the lung function and reduce the use of systematic corticosteroids in acute asthma, but the potency to reduce the number of patients with hospitalization and treatment failure need to be explored in future.

Citation： ZHANG Hongping,LV Yan,LIANG Rui,JIA Chune,JIANG Yunqiu,WANG Lei,WANG Li,WANG Gang. Efficacy and Safety of Montelukast in Treatment of Acute Asthma in Adults: A Systematic Review. Chinese Journal of Respiratory and Critical Care Medicine, 2012, 11(4): 335-341. doi: Copy

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