SUN Zhongdong 1 , GAO Shangzhi 2 , MAO Zhifu 2
  • (1.Department of Cardiovascular Surgery, Qingdao Municipal Hospital, Medical College of Qingdao University, Qingdao 266071, Shandong, P.R. China;;
  • ;;
  • 2.Department of Thoracic and Cardiovascular Surgery, Renmin Hospital of Medical College, Wuhan University, Wuhan 430060, P.R. China);
Renal ischemic preconditioning; Myocardial protection; Immature myocardium
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Objective To investigate the immature myocardial protection effects with renal ischemic preconditioning. Methods 18 neonatal rabbits were randomly divided into three groups. Ischemic/reperfusion(I/R) group underwent 45 min ischemia followed with 45 min reperfusion after Langendorff model performed. Cardiac ischemic preconditioning(CIP) group underwent 45 min ischemia followed with 45 min reperfusion after 5 min ischemia and then 5 min reperfusion for two times. Renal ischemic preconditioning(RIP) group underwent 45 min ischemia followed with 45 min reperfusion after renal artery obstruction for 5 min and 5 min reperfusion for three times.The left ventricular function recovery,myocardial water content(MWC), lactate dehydrogenase (LDH) and creatine kinase(CK) leakage, malondialdehyde(MDA) content,adenosine triphosphate(ATP) content, superoxide dismutase(SOD) activity, myocardial cell Ca2+ ［Ca2+］c content,mitochondrial Ca 2+ content ［Ca2+］m,synthesizing ATP activity of mitochondria ［ATP］m and Ca2+ATPase activity of mitochondria ［Ca2+ATPase］m were tested. Results The recovery of postischemic heart function in RIP group and CIP group were higher than that I/R group(P lt;0.01). There were no significant difference of HR, AF in three groups （P gt;0.05）. There were significant difference of CF，CO，LVSP and LVEDP in RIP group and CIP group than those I/R group（P lt;0.01）. There were significant difference of MWC, CK, LDH, ATP content, MDA, SOD activity, ［Ca2+］c content, ［Ca2+ATPase］m， ［Ca2+］m and ［ATP］m in RIP group than those I/R group（P lt;0.01). There were no significant difference between RIP group and CIP group upon every index (P gt;0.05). Conclusion RIP has the same cardioprotection to immature myocardium as ischemic preconditioning.

Citation： SUN Zhongdong,GAO Shangzhi,MAO Zhifu,WANG Zhiwei,WU Zhiyong. Preservation Effect of Immature Myocardium with Renal Ischemic Preconditioning in Neonatal Rabbits. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2008, 15(3): 204-207. doi: Copy

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