Objective To investigate the influence of collagen on the biomechanics strength of tissue engineering tendon. Methods All of 75 nude mice were madethe defect models of calcaneous tendons, and were divided into 5 groups randomly. Five different materials including human hair, carbon fibre (CF), polyglycolic acid (PGA), human hair and PGA, and CF and PGA with exogenous collagen were cocultured with exogenous tenocytes to construct the tissue engineering tendons.These tendons were implanted to repair defect of calcaneous tendons of right hind limb in nude mice as experimental groups, while the materials without collagenwere implanted to repair the contralateral calcaneous tendons as control groups. In the 2nd, 4th, 6th, 8th and 12th weeks after implantation, the biomechanicalcharacteristics of the tissue engineering tendon was measured, meanwhile, the changes of the biomechanics strength were observed and compared. Results From the 2nd week to the 4th week after implantation, the experimental groups were ber than the control groups in biomechanics, there was statistically significantdifference (P lt;0.05). From the 6th to 12th weeks, there was no statisticallysignificant difference between the experiment and control groups (P gt;0.05). Positivecorrelation existed between time and intensity, there was statistically significant difference (P lt;0.05). The strength of materials was good in human hair,followed by CF, and PGA was poor. Conclusion Exogenous collagen can enhance the mechanics strength of tissue engineering tendon, and is of a certain effect on affected limb rehabilitation in early repair stages.

Citation： FANG Yue,YANG Zhiming.. EXPERIMENTAL STUDY ON BIOMECHANICS CHARACTERISTICS OF COMBINED COLLAGEN TISSUE ENGINEERING TENDON. Chinese Journal of Reparative and Reconstructive Surgery, 2005, 19(4): 318-321. doi: Copy

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