• Department of Orthopedic surgery;;
  • First Univerisity Hospital;;
  • West China University of Medical Sciences;;
  • Chengdu;;
  • P.R.China 610041;;
Insulin-like growth factor-1; Receptor; Tendon cell; Proliferation control; Culture in vitro
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The purpose of this study was to find some solutions to the problem of tendon cell proliferation control. Under the condition of in vitro culture, several materials including IGF-1 receptor antibody and mRNA antisense oligonucleotide were added to the culture medium to block the IGF-1-Receptor system. The effect of the material on the tendon cell proliferation was judged by cell count after incubation of 48 hours. The results showed that both IGF-1 Receptor antibody (IGF-1R alpha) and IGF-1 Receptor mRNA antisense oligonucleotide had negative effect on tendon cell proliferation (P  lt; 0.01 and P  lt; 0.05). These findings lead us to think that the above two materials could be used in the experiment of tendon adhesion preventing and living ready-made tendon producing.

Citation： Xiang Zhou,Yang Zhiming,Zhang Caoliang et al.. THE EFFECT OF BLOCKING INSULIN-LIKE GROWTH FACTOR-1 (IGF-1)RECEPTOR SYSTEM ON TENDON CELL PROLIFERATION. Chinese Journal of Reparative and Reconstructive Surgery, 1998, 12(1): 35-38. doi: Copy

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