Objective To investigate the characteristics and diagnostic value of fundus fluorescein angiography (FFA) for familial exudative vitreoretinopathy (FEVR). Methods 34 children (68 eyes) with FEVR and 64 parents (128 eyes) were included. All the clients were received examinations of slit-lamp biomicroscopy and indirect ophthalmoscopy. Meanwhile the children were examined by RetcamⅡ,the best corrected visual acuity of parents were recorded. The children and their parents were classified according to the ocular findings. Among 68 eyes of children, 3 eyes (4.41%) were normal, 4 eyes (5.88%) were in stage 1, 7 eyes (10.29%) were in stage 2, 2 eyes (2.94%) were in stage 3, 8 eyes (11.76%) were in stage 4 and 44 eyes (64.71%) were in stage 5. Among 128 eyes of parents, 74 eyes (57.81%) were normal, 51 eyes (39.84%) were in stage 1, 1 eyes (0.78%) were in stage 2 and 2 eyes (1.56%) were in stage 5. FFA was performed on the children with RetcamⅡunder anesthesia and on the parents with HR2 in order to observe the FFA characteristics in different stage. Results FFA characteristics in children included uncompleted vascularization of the periphery, peripheral avascular zone (stage 1); neovascularization and/or peripheral subretinal and intraretinal exudation (stage 2); subtotal retinal detachment with attached fovea (stage 3); subtotal retinal detachment with detached fovea (stage 4) and total retinal detachment (stage 5). FFA characteristics in parents included abrupt cessation of the peripheral retinal capillary network and a peripheral avascular zone (stage 1); abnormal peripheral arteriovenous shunts, neovascularization or exudation (stage 2) and atrophia bulbi (stage 5). Conclusions FEVR in different stage has different FFA characteristics. FFA plays an important role in early diagnosis of FEVR.
Citation: 张琦,赵培泉. Characteristics and diagnostic value of fundus fluorescein angiography for familial exudative vitreoretinopathy. Chinese Journal of Ocular Fundus Diseases, 2011, 27(3): 263-266. doi: Copy
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