Objective To observe the clinical characteristics of diabetic neovascularization on the disc (DNVD).Methods The clinical data of 526 patients (1052 eyes) who were diagnosed as diabetes in Department of intern medicine, as diabetic retinopathy by ophthalmoscope and fundus fluorescein angiograph (FFA) was retrospectively reviewed. All patients were carried out with best corrected visual acuity（BCVA）, slitlamp microscope,ophthalmoscope and FFA after mydriasis. In which, who has neovascularization on the optic disc with ophthalmoscopy and FFA examination were included in this study.The relationship between the occurrence and development of DNVD and phase of DR, disease duration, the level of blood glucose and panretinal photocoagulation were analyzed. Results DNVD was found in167/1052eyes (15.87%). There were 91 eyes (54.49%) with BCVA＜0.1, 58 eyes (34.73%) with BCVA＜0.4 but ge;0.1，and 18 eyes(19.78%) with BCVA ge;0.4. Retinal neovascularization was located in the surface of disc surface or within 1PD from the optic disc；Those vessels filled early and rapidly, and with local b fluorescence due to fluorescence leakage at middle and late stage of FFA examination.All 167 DNVD eyes are proliferative diabetic retinopathy (PDR) with 43 eyes (25.75%) in stage IV,52 eyes (31.14%) in stage V and 72 eyes (43.11%) in stage VI.Of those DNVD eyes,there were 5 eyes (2.99%) with course of diabetes ＜3 years,12 eyes (7.19%) s＜5 years but ge;3 years, 21 eyes (12.57%)＜10 but ge;5 years, 56 eyes (33.53%)＜15 but ge;10 years and 73 eyes (43.71%) ge;15 years. There were 15 eyes (8.98%) with fasting blood glucose (FBG)＜7.0 mmol/L,26 eyes (15.57%) with FBG＜9.0 but ge;7.0 mmol/L,50 eyes (29.94%) with FBG＜12.0 but ge;9.0 mmol/L and 76 eyes (45.51%) with FBG ge;12.0 mmol/L;there were 28 eyes (16.77%) with 2 hour postprandial blood glucose（2hPBG）＜10.0 mmol/L, 35 eyes (20.96%) with 2hPBG＜12.0 but ge;10.0 mmol/L,42 eyes (25.15%) with 2hPBG ＜16.0 but ge;12.0 mmol/L and 62 eyes (50.30%) with 2hPBG ge;16.0 mmol/L. The occurrence of DNVD and duration of diabetes, FBG and 2hPBG were all positively correlated (r=0.991,0.984,0.960, P=0.001, 0.016, 0.040) by the Person correlation analysis. 15 eyes (5.84%) of DNVD happened in 257 eyes who treated with PRP in severe nonproliferative diabetic retinopathy (NPDR),152 eyes (19.12%) DNVD happened in 795 eyes who untreated with PRP in severe NPDR，the differences were statistically significant ( chi;2=25.659,P＜0.01) between them.Conclusion DNVD happened commonly in DR, the occurrence of DNVD is intensive related with diabetic retinopathy stage,duration of diabetes,FBG and PBG.
Citation： 谭叶辉,吴国基,邵毅,肖启国. Clinical characteristics of neovascularization on the optic disc in diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2010, 26(2): 131-134. doi: Copy
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