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Objective To observe the inhibiting effects of alginate sodiumretinoic acid(AGS-RA)microspheres release system on the laser coagulationinduced subretinal proliferation.Methods RA were dissolved by absolute alcohol,then mixed with 1.5% AGS and made into AGSRA microspheres by a microcapsule electrostatic generator. The parameter of laser injury include irradiation time (0.20 s),spot diameter (200  mu;m) and output power (420 mW).Thirty pigmented rabbits were randomly divided into 3 groups (laser injury,experimental and control group).After laser coagulation,AGSRA or blank microspheres were immediately injected into the vitrous of experimental and control rabbits respectively.The height,width and area of 6 retinal spots of laser coagulation at each timepoint were analyzed histopathologically with serial retinal sections at 1,2,3,4,and 6 weeks after laser coagulation.Results Histopathological examination showed that there were morphological and distribution changes of retinal cells in all layers, and localized fibroblasts proliferation in the retina after laser injury. The laserinduced responses in experimental group were much milder(P<0.01), while the laser injury group and control group have same width(P>0.05)and height/area of laser spots(P>0.05).Conclusion AGSRA release system can alleviate the subretinal proliferate after laser injury.

Citation: 王凤翔,何守志,李新建,梁秋丽,陈兵. Alginate sodiumretinoic acid microspheres suppress the subretinal proliferation after laser coagulation. Chinese Journal of Ocular Fundus Diseases, 2009, 25(4): 297-300. doi: Copy

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