Evaluation of Accuracy and Quality of Diagnostic Test of ECLIA in Detecting AFP for the Diagnosis of Liver Cancer in Chinese Patients_Chinese Journal of Evidence-Based Medicine

Authors：

HUANG Ping ¹ ,  WU Taixiang ²

1.Department of Laboratory Medicine, West China School of Clinical Medicine, Sichuan University, Chengdu 610041, China 2.Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

WU Taixiang, Email: txwutx@hotmail.com

Keywords：

ECLIA; AFP; Diagnostic test; Accuracy; Evaluation

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To evaluate the accuracy and quality of diagnostic test of Electrochemiluminescence immunoassay (ECLIA) in detecting A-fetal protein (AFP) for the diagnosis of liver cancer in Chinese patients.
Methods 　We searched Chinese Biological Medicine Database (CBM, 1978 to 2005) and China National Knowledge Infrastructure (CNKI, 1994 to 2005). Diagnostic tests of ECLIA in detecting AFP for the diagnosis of liver cancer were included. Data were extracted, and the quality of included studies was evaluated according to the six criteria of diagnostic tests.
Results　 Forty-eight studies were identified, but only 6 were included and none mentioned the indices about the accuracy.
Conclusion 　The number of studies of ECLIA in detecting AFP for the diagnosis of liver caner is few and the quality is poor. We cannot draw the conclusion that ECLIA is better for sensitivity and specificity.

Citation： HUANG Ping,WU Taixiang. Evaluation of Accuracy and Quality of Diagnostic Test of ECLIA in Detecting AFP for the Diagnosis of Liver Cancer in Chinese Patients. Chinese Journal of Evidence-Based Medicine, 2006, 06(6): 459-463. doi: Copy

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1. 汤利猷. 原发性肝癌. 见: 姚光弼, 主编. 临床肝脏病学. 第1版. 上海: 上海科学技术出版社; 2004.
2. 中国抗癌协会肝癌专家委员会. 原发性肝癌诊断标准. 中华肝脏病杂志, 2000; 8: 135.
3. (德) 托马斯, 主编. 朱汉民, 沈霞, 等, 译. 临床实验诊断学－试验结果的应用和评价. 第1版. 上海: 上海科学技术出版社; 2004. 5.
4. 吴泰相, 刘关键, 王家良. 医学检验方法学研究的设计和文献评价原则. Chinese Journal of Laboratory Medicine, 2000; 23(6): 379-381.
5. 吴泰相, 李萍. 循证实验医学. 黄文方, 刘华, 主编. 实用医学分析技术与应用. 北京: 人民卫生出版社, 2002.
6. 王家良, 主编. 临床流行病学. 第2版. 北京: 人民卫生出版社, 2004.
7. 于瑞宝, 王爱英. 电化学发光免疫法与放射免疫法检测血清AFP的比较. 齐鲁医学杂志, 2001; 16(2): 125-126.
8. 肖小慧, 彭献香, 龚启斌, 等. 电化学发光与放射免疫检测甲胎蛋白的比较. 实用医学杂志, 2002; 18(12): 1345.
9. 卢业成, 刘丽儿, 邝燕玲, 等. 电化学发光免疫分析法在AFP定量检测中的应用. 标记免疫分析与临床, 2003; 10(4): 232-234.
10. 邝妙欢, 林翠杏, 刘万里, 等. 两种方法检测血清甲胎蛋白（AFP）的比较. 国际医药卫生导报, 2003; 9(11): 9-10.
11. 盂凡华, 江梅, 郑彩云. 电化学发光免疫法测定甲胎蛋白的临床评价. 临床军医杂志, 2004: 32(3): 93-94.
12. Tang LY. Primary Liver Cancer. Yao GB, editor-in-chief. Clinical Hepatology. 1st ed. Shanghai: Shanghai Science & Technology Press, 2004.
13. The expert committee of Chinese anticancer association. diagnostic standard of primary liver cancer. Chinese liver disease, 2000; 8: 135.
14. Thoms, editor-in-chief clinical laboratory diagnostics－application and appraisal of experiment result. Shanghai: Shanghai Science & Technology Press, 2004; 5.
15. Wu TX, Liu GJ, Wang JL. The design and literature appraisal principle of the methodology of laboratory medicine. Chinese examination medicine, 2000; 23(6): 379-381.
16. Wu TX, Li P. Evidence-based Laboratory Medicine. Huang WF, Liu H, editor-in-chief, Practical Medical Analysis Technology and Application. Beijing: People’s Medical Publishing House, 2002.
17. Wang JL, editor-in-chief. Clinical epidemiology. 2nd eds. Beijing: People’s Medical Publishing House, 2004.
18. Yu RB, Wang AY. A Comparision of Ria and Eclia in Serum AFP Determination. Medical Journal of Qilu, 2001; 16(2): 125-126.
19. 李倩, 高学慧, 甘勇, 等. 电化学发光与酶联免疫检测血清甲胎蛋白的比较. 中华检验医学杂志, 2001; 24(4): 243.
20. Xiao XH, Peng XX, Gong QB, et al. Comparing ECLIA with RIA in detecting serum AFP. The Journal of Practical Medicine, 2002; 18(12): 1345.
21. Lu YC, Liu LE, Kuang YL. Electro-chemiluminescence Immunoassay for Quantitative Determination of AFP. Labeled Immunoassays & Clin Med, 2003; 10(4): 232-234.
22. Kuang MH, Lin CX, Liu WL, et al. Comparison of Two Methods for Detection of the Levels of Serum AFP. International Medicine & Health Guidance News, 2003; 9(11): 9-10.
23. Meng FH, Jiang M. Clinical Evaluation of Electrochemiluminescence Immunoassay for Determination of AFP. Clin J Med Offic, 2004; 32(3): 93-94.
24. Sheps SB, Schechter MT. The assessment of diagnostic tests. A survey of current medical research. JAMA, 1984; 252(17): 2418-2422.

Chinese Journal of Evidence-Based Medicine

Evaluation of Accuracy and Quality of Diagnostic Test of ECLIA in Detecting AFP for the Diagnosis of Liver Cancer in Chinese Patients

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