Effects of Isoflurane on Learning and Memory in Aged Rats_West China Medical Journal

Authors：

CHEN Li ¹ ,  WANG Xiao ¹ , YANG Jing ¹ , ZHANG Huiwei ²

1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China; 2. Department of Anesthesiology, the First People’s Hospital of Leshan City, Leshan, Sichuan 614000, P. R. China;

Corresponding author：

WANG Xiao, Email: chenli0763@163.com

Keywords：

异氟醚; Y迷宫实验; 学习记忆能力; 大鼠

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目的　探讨异氟醚吸入麻醉对（SD）老年大鼠学习和记忆的影响。方法　 36只SD健康雄性大鼠随机分为异氟醚麻醉组和对照组，每组各18只。麻醉组给予2%异氟醚和40%氧气诱导及维持麻醉3 h，对照组单纯吸入含40%氧气的空氧混合气体3 h。麻醉组或对照组干预结束24 h后开始为期1周的盲法测试学习记忆能力。结果　麻醉组大鼠与对照组大鼠相比，Y-迷宫测试成绩错误反应次数差异无统计学意义（P＞0.05）；除第7天麻醉组大鼠起步电压高于对照组（P＜0.05）外，其余时间两组大鼠起步电压差异均无统计学意义（P＞0.05）；除第3天麻醉组大鼠跑步电压高于对照组（P＜0.05）外，其余时间两组大鼠跑步电压差异均无统计学意义（P＞0.05）。结论　2%单纯异氟醚吸入麻醉不改变老年大鼠麻醉后学习和记忆能力。

Citation： CHEN Li,WANG Xiao,YANG Jing,ZHANG Huiwei. Effects of Isoflurane on Learning and Memory in Aged Rats. West China Medical Journal, 2012, 27(3): 372-374. doi: Copy

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1. 　王跃春. Y型电迷宫在大鼠学习记忆功能测试中的合理运用[J]. 中国行为医学科学, 2005, 14(1): 69-70.
2. 　王跃春. 大鼠Y型迷宫测试法的筛选与优化[J]. 中国行为医学科学, 2005, 14(1): 50-52.
3. 　Butterfield NN, Graf P, Ries C, et al. The effect of repeated isoflurane anesthesia on spatial and psychomotor performance in young and aged mice[J]. Anesth Analg, 2004, 98(5): 1305-1311.
4. 　Culley DJ, Baxter M, Yukhananov R, et al. The memory effects of general anesthesia persist for weeks in young and aged rats[J]. Anesth Analg, 2003, 96(4): 1004-1009.
5. 　徐静, 万燕杰, 曾因明. 脾切除术对大鼠空间学习记忆能力的影响[J]. 中华麻醉学杂志, 2006, 26(2): 144-146.
6. 　袁力勇, 戴体俊, 王霞民, 等. 咪达唑仑与盐酸戊乙奎醚对小鼠学习记忆获得和巩固及再现的影响[J]. 医药导报, 2008, 27(1): 7-10.
7. 　Cibelli M, Fidalgo, AR, Terrando N, et al. Role of interleukin-1beta in postoperative cognitive dysfunction[J]. Ann Neurol, 2010, 68(3): 360-368.
8. 　Cao XZ, Ma H, Wang JK, et al. Postoperative cognitive deficits and neuroinflammation in the hippocampus triggered by surgical trauma are exacerbated in aged rats[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34(8): 1426-1432.
9. 　Perucho J, Rubio I, Casarejos MJ, et al. Anesthesia with isoflurane increases amyloid pathology in mice models of Alzheimer’s disease[J]. J Alzheimers Dis, 2010, 19(4): 1245-1257.
10. 　Wang Y, Sands LP, Vaurio L, et al. The effects of postoperative pain and its man agement on postoperative cognitive dysfunction[J]. Am J Geriatr Psychiatry, 2007, 15(1): 50-59.
11. 　冯昌栋, 戴体俊. 异氟醚全麻机制的研究进展[J]. 国外医学·麻醉学与复苏分册, 2002, 23(6): 327-329.
12. 　肖春红, 郭安梅, 郭素香. 异氟醚对认知功能的影响机制[J]. 现代生物医学进展, 2010, 10(17): 3382-3383.

West China Medical Journal

Effects of Isoflurane on Learning and Memory in Aged Rats

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