Analysis of Effectiveness and Drug Resistance in Patients with AIDS Receiving Highly Active Antiretroviral Therapy_West China Medical Journal

Authors：

YANG Chengbin ¹ ,  FENG Ping ² , CEN Yihu ¹ , LIANG Cheng ¹

1. The People’s Hospital of Butuo County, Butuo, Sichuan 616350, P. R. China; 2. Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

FENG Ping, Email: ycb20088@163.com

Keywords：

艾滋病; 耐药性; 高效抗逆转录病毒疗法; 病毒载量

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【摘要】　目的　评价高效抗逆转录病毒疗法（highly active antiretroviral therapy，HAART）对艾滋病患者的疗效，并观察其耐药情况。　方法　 2008年11月，对23例接受免费HAART治疗1~3年的艾滋病患者的HIV-RNA病毒载量、HIV-1耐药、CD4+T淋巴细胞绝对计数、常规生化检测结果进行分析。　结果　 23例艾滋病患者在HAART治疗1~3年后有6例（26.1%）患者HIV-RNA载量在水平线以下，17例（73.9%）HIV-RNA载量未达到检测线以下。5例患者（21.7%）的HIV-1发生了耐药，服药依从性良好的患者仅9例（39.1%）。　结论　 HAART对艾滋病患者的疗效较差、耐药率高、服药依从性差。
【Abstract】　Objective　 To evaluate the efficacy of highly active antiretroviral therapy (HAART) in treating HIV, and observe the resistance of HAART in AIDS patients.　Methods　 Twenty-three HIV patients receiving free HAART for one to three years were investigated. The plasma viral load, drug resistance to HIV-1, CD4+ T cell count were tested and routine laboratory examinations were performed in our study.　Results　 After one to fhnee-year HAART treatment, HIV viral load of six patients (26.1%) declined to the undetectable level, while the viral load of 17 patients (73.9%) kept at a high level. Resistance to HIV-1 occurred in five cases (21.7%). Only nine patients (39.1%) had good treatment compliance.　Conclusion　 HAART has a poor therapeutic effect on patients with HIV/AIDS with a high rate of drug resistance and poor treatment compliance.

Citation： YANG Chengbin,FENG Ping,CEN Yihu,LIANG Cheng. Analysis of Effectiveness and Drug Resistance in Patients with AIDS Receiving Highly Active Antiretroviral Therapy. West China Medical Journal, 2011, 26(3): 424-426. doi: Copy

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1. 　张福杰, 文毅, 于兰, 等. 艾滋病的抗病毒治疗与我国的免费治疗现状[J]. 科技导报, 2005, 23(7): 24-29.
2. 　张福杰, 李太生, 王建, 等. 国家免费艾滋病抗病毒治疗手册[M]. 2版. 北京: 人民出版社, 2008: 12-16.
3. 　代丽丽, 杨瑞侃, 周舜泰. 抗反转录病毒治疗[M]. 艾滋病诊疗学, 2009: 54-85.
4. 　Montaner JS, Reiss P, Cooper D, et al. A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: the INCAS trial. Italy, The Netherlands, Canada and Australia Study[J]. JAMA, 1998, 279(2): 930-937.
5. 　Bangsbery DR, Hecht FM, Charlebois ED, et al. Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population[J]. AIDS, 2000, 14(1): 357-366.
6. 　Paterson DL, Swindells S, Mohr J, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection[J]. Ann Intern Med, 2000, 133(1): 21-30.
7. 　Shet A, Markowitz M. Transmitted multidrug resistant HIV-1; new and investigational therapeutic approaches[J]. Curr Opin Investig Drugs, 2006, 7(8): 709-720.
8. 　刘明斌, 熊志伟, 徐丹, 等. HIV耐药的研究进展[J]. 中国艾滋病性病, 2007, 13(6): 588-590.
9. 　张福杰, 尚红, 吴昊主. 艾滋病诊疗学(2007年版)[M]. 北京: 人民卫生出版社, 2009: 246-270.

West China Medical Journal

Analysis of Effectiveness and Drug Resistance in Patients with AIDS Receiving Highly Active Antiretroviral Therapy

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