Expression of E-cadherin in Invasive Ductal Carcinoma of the Breast and Its Significance_West China Medical Journal

Authors：

LIU Guitao ¹ , LI Xia ²

1. Department of Occupational Diseases Prevention, 2. Department of Geriatrics, the Fifth Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang 830011, P. R. China;

Corresponding author：

Keywords：

乳腺浸润性导管癌; 表皮钙黏蛋白; 免疫组织化学; 表达

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【摘要】　目的　探讨乳腺浸润性导管癌中表皮钙黏蛋白（E-cadherin，E-cad）的表达及其意义。　方法　选取2005年1月－2009年12月的组织病理切块，用免疫组织化学EnVision二步法检测63例乳腺浸润性导管癌（invasive ductal carcinoma，IDC）组织中E-cad的表达情况，设为IDC组；另检测15例乳腺纤维腺瘤及15例乳腺小叶增生症乳腺组织中E-cad的表达情况，设为对照组；比较两组的E-cad表达。　结果　 E-cad在IDC组及对照组中表达阳性率分别为58.7%、80.0%；两组间差异有统计学意义（P lt;0.05）。在乳腺IDC患者中，年龄 lt;38岁和≥38岁组的E-cad阳性表达率分别是54.2%、61.5%，两组间差异无统计学意义（P gt;0.05）；肿块直径 lt;3 cm和≥3 cm组的E-cad阳性表达率分别是54.8%、66.7%，两组间差异无统计学意义（P gt;0.05）；组织学分级为Ⅰ+Ⅱ级和Ⅲ级组的E-cad阳性表达率分别是76.3%、32.0%，两组间差异有统计学意义（P lt;0.05）；无、有腋窝淋巴结转移组的E-cad阳性表达率分别是78.3%、47.5%，两组间差异有统计学意义（P lt;0.05）。　结论　 E-cad的表达与患者年龄及肿块大小无关，而与组织学分级、淋巴结转移相关。在乳腺浸润性导管癌中，无淋巴结转移者E-cad表达高于有淋巴结转移者，提示E-cad是乳腺浸润性导管癌发生淋巴结转移的重要指标。
【Abstract】　Objective　 To explore the expression of the protein E-cadherin (E-cad) in invasive ductal carcinoma (IDC) of the breast and its significance.　Methods　 We chose 63 cases of pathological wax with IDC between 2005 and 2009, and immunohistochemical EnVision method was used to detect the expression of E-cad protein in these cases which were designated to be the IDC group. At the same time, the E-cad expression in 15 cases of breast adenoma and another 15 cases of breast lobular hyperplasia were also detected, and these cases were designed to the the control group. The expression of E-cad in these two groups were compared.　Results　 The positive rates of E-cad protein expression in the IDC group and the control group were respectively 58.7% and 80.0% with a significant difference between the two groups (P lt;0.05). In the IDC group, the positive rates of E-cad protein expression in patients aged lt;38 and ≥38 years old were respectively 54.2% and 61.5% without a significant difference (P gt;0.05). The positive rates of E-cad protein expression for tumors with a diameter lt;3 cm and ≥3 cm were respectively 54.8% and 66.7% without a significant difference (P gt;0.05). The positive rates of E-cad protein expression for class Ⅰ+Ⅱ tumors and class Ⅲ tumors were respectively 76.3% and 32.0% with a significant difference (P lt;0.05). The positive rates of E-cad protein expression for patients without and with axillary lymph node metastasis were respectively 78.3% and 47.5% with a significant difference (P lt;0.05).　Conclusions　 The expression of E-cad is correlated with histological classification and lymph node metastasis and was not related to tumor size and age of the patients. The expression of E-cad is higher in IDC patients without lymph node metastasis than that in IDC patients with lymph node metastasis, which indicates that E-cad is an important index for lymph node metastasis of IDC.

Citation： LIU Guitao,LI Xia. Expression of E-cadherin in Invasive Ductal Carcinoma of the Breast and Its Significance. West China Medical Journal, 2011, 26(7): 983-985. doi: Copy

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1. 　陈杰, 李甘地. 病理学[M]. 北京: 人民卫生出版社, 2005: 383.
2. 　谷化平, 尚培中, 刘艳茹. CD44v6和Ecadherin表达与乳腺癌生物学行为的关系[J]. 中国癌症杂志, 2002, 12(3): 217-219.
3. 　Berx G, Staes K, van Hengel J, et al. Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1)[J]. Genomics, 1995, 26(2): 281-289.
4. 　Bussmahers MJG, Bokhoven AV, Mees SGM, et al. Molecular cloning and characterization of the human E cadherinc DNA[J]. Molbiol Rep, 1993, 17(2): 123-128.
5. 　Eidelman S, Damsky CH, Wheelock MJ, et al. Expression of the cell adhesion glycoprotein cell CAM120/80 in normal human tissues and tumors[J]. Am J Pathol, 1989, 135(1): 101-110.
6. 　Hermiston ML, Gordon JI. In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death[J]. J Cell Biol 1995, 129(2): 489-506.
7. 　刘奕彬, 凌彬, 马旭东, 等. E-cad和CD44v6在口腔鳞癌中的表达及意义[J]. 国际口腔医学杂志, 2007, 34(5): 325-327.
8. 　易明福, 魏晓梅. E-cad、CD44v6基因表达与非小细胞肺癌淋巴转移的关系[J]. 临床肺科杂志, 2010, 15(2): 157-158.
9. 　Kurtz KA, Hoffman HT, Zimmerman MB, et al. Decreased E-cadherin but not beta-catenin expression is associated with vascular invasion and decreased survival in head and neck squamous carcinomas[J]. Otolaryngol Head Neck Surg, 2006, 134(1): 142-146.
10. 　Chen TT, Yuan DT, Wei B, et al. E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation[J]. Stem Cells, 2010, 28(8): 1315-1325.
11. 　刘文清, 高双全, 黄伟, 等. KAI1/CD与E-cadherin在结直肠癌的表达与预后的关系[J]. 华西医学, 2009, 24(8): 1954-1956.
12. 　Kwak JM, Min BW, Lee JH, et al. The prognostic significance of E-cadherin and liver intestine-cadherin expression in colorectal cancer[J]. Dis Colon Rectum, 2007, 50(11): 1873-1880.
13. 　Choi HN, Kim KR, Lee JH, et al. Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/beta-catenin complex[J]. Oncol Rep, 2009, 21(1): 57-63.
14. 　李宇清, 梅开勇, 陆光明. 乳腺癌中E-cadherin、CerbB-2、p53、Ki-67的表达及其临床意义[J]. 现代医院, 2009, 9(8): 2-4.

West China Medical Journal

Expression of E-cadherin in Invasive Ductal Carcinoma of the Breast and Its Significance

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