实时荧光显像在胶质瘤术中应用的研究进展_West China Medical Journal

Authors：

余水 ,  毛庆

Corresponding author：

毛庆, Email: shuiyu-ys@163.com

Keywords：

δ-氨基-γ-酮戊酸; 荧光素钠; 纳米荧光探针; 靛氰绿; 多光子; 胶质瘤术

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【摘要】胶质瘤是中枢神经系统发病率最高的恶性肿瘤，目前的治疗方法是以手术为主、放化疗为辅的分级分型个体化综合治疗，其中手术为最快速和有效去除肿瘤组织的手段。由于肿瘤常呈浸润性生长，术中肿瘤边界显示不清，要达到术中全切非常困难。提高肿瘤边界判断的准确性，以助于术者最大限度地切除肿瘤，便成为改善患者预后的主要方法。术中实时荧光显像技术为近年来蓬勃发展的判断肿瘤边界的新技术。目前国际上荧光显像方法主要有δ-氨基-γ-酮戊酸、荧光素钠、纳米荧光探针、靛氰绿、多光子激发荧光等引导的荧光显像法，前两者相对较成熟而后三者仍处于研究之中。本文就术中实时荧光显像在胶质瘤术中应用进行阐述。

Citation： 余水,毛庆. 实时荧光显像在胶质瘤术中应用的研究进展. West China Medical Journal, 2010, 25(7): 1385-1387. doi: Copy

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12.	Hansen D, Spence A, Carski T, et al. Indocyanine green(ICG)staining and demarcation of tumormargins in a rat glioma model[J]. Surg Neurol, 1993, 40(6): 451-456.
13.	Haglund M, Hochman D, Berger M, et al. Enhanced optical imaging of rat gliomas and tumor margins[J]. Neuro Surg, 1994, 35(5): 930-940.
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18.	顾小宇, 尚寒冰, 赵卫国, 等. 脑胶质瘤术中荧光显像的实验研究[J]. 中国微侵袭神经外科杂志, 2009, 14(10): 456-458.
19.	Park MH, Ahn BH, Hong YK, et al. Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-κB/Sp1-mediated signaling pathways[J]. Carcinogenesis, 2009, 30(2): 356-365.
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1. Stummer W, Stocker S, Wagner S, et al. Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence[J]. Surg Neurol, 1998, 42(3): 518-526.
2. Stummer W, Novotny A, Stepp H, et al. Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients[J]. Neurosurg, 2000, 93: 1003-1013.
3. Stummer W, Pichlmeier U, Meinel T, et al. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase Ⅲ trial[J]. Lancet Oncol, 2006, 7(5): 392-401.
4. Kuroiwa T, Kajimoto Y, Ohta T, et al. Development of a fluorescein operative microscope for use during malignant glioma surgery-a technical note and preliminary report[J]. Surg Neurol, 1998, 50(1): 41-49.
5. Shinoda J, Yano H, Yoshimura S, et al. Fluorescence-guided resection of glioblastoma multiforme by using high-dose fluorescein sodium. Technical note[J]. J Neurosurg, 2003, 99(3): 597-603.
6. 胡新华, 张岩松, 刘翔, 等. 荧光导航辅助下切除功能区恶性胶质瘤[J]. 中国微侵袭神经外科杂志, 2006, 11(8): 343-344.
7. 张岩松, 常义, 刘宏毅, 等. 荧光导航技术在颅内恶性胶质瘤手术中的应用[J]. 临床神经病学杂志, 2006, 19(1): 56-57.
8. Okuda T, Kataoka K, Taneda M. Metastatic brain tumor surgery using fluorescein sodium: technical note[J]. Minim Invasive Neurosurg, 2007, 50(6): 382-384.
9. Moritz F, Mahmood U, Raymond S, et al. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation[J]. Cancer Res, 2003, 63(23): 8122-8125.
10. Veiseh O, Sun C, Gunn J, et al. Optical and MRI multifunctional nanoprobe for targeting gliomas[J]. Nano Letters, 2005, 5(6): 1003-1008.
11. Hockaday DC, Shen S, Fiveash J, et al. Imaging glioma extent with 131I-TM-601[J]. Nucl Med, 2005, 46(4): 580-586. [12] Veiseh M, Gabikian P, Bahrami SB, et al. Tumor paint: A chlorotoxin: Cy5. 5 bioconjugate for intraoperative visualization of cancer foci[J]. Cancer Res, 2007, 67(14): 6882-6888.
12. Hansen D, Spence A, Carski T, et al. Indocyanine green(ICG)staining and demarcation of tumormargins in a rat glioma model[J]. Surg Neurol, 1993, 40(6): 451-456.
13. Haglund M, Hochman D, Berger M, et al. Enhanced optical imaging of rat gliomas and tumor margins[J]. Neuro Surg, 1994, 35(5): 930-940.
14. Haglund M, Berger M, Hochman D, et al. Enhanced optical imaging of human gliomas and tumor margins[J]. Neuro Surg, 1996, 38(2): 308-317.
15. Gavin W, Ghatan S, Alexander M, et al. Intracarotid RMP-7 enhanced indocyanine green staining of tumors in a rat. glioma model[J]. Neurooncol, 2002, 56(3): 227-232.
16. Leppert J, Krajewski J, Kantelhardt SR, et al. Multiphoton excitation of autofluorescence for microscopy of glioma tissue[J]. Neurosurg, 2006, 58: 759-767.
17. Ichioka T, Miyatake S, Asai N, et al. Enhanced detection of malignant glioma xenograft by fluorescein-human serum albumin conjugate[J]. J Neurooncol, 2004, 67(1-2): 47-52.
18. 顾小宇, 尚寒冰, 赵卫国, 等. 脑胶质瘤术中荧光显像的实验研究[J]. 中国微侵袭神经外科杂志, 2009, 14(10): 456-458.
19. Park MH, Ahn BH, Hong YK, et al. Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-κB/Sp1-mediated signaling pathways[J]. Carcinogenesis, 2009, 30(2): 356-365.
20. McGirt MJ, Chaichana KL, Attenello FJ, et al. Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas[J]. Neurosurgery, 2008, 63(4): 700-708.
21. Mcgirt MJ, Chaichana KL, Gathinji M, et al. Independent association of extent of resection with survival in patients with malignant brain astrocytoma[J]. J Neurosurg, 2009, 110(1): 156-162.

West China Medical Journal

实时荧光显像在胶质瘤术中应用的研究进展

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